Gene description for DDX43
Gene name DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
Gene symbol DDX43
Other names/aliases CT13
HAGE
Species Homo sapiens
 Database cross references - DDX43
ExoCarta ExoCarta_55510
Vesiclepedia VP_55510
Entrez Gene 55510
HGNC 18677
MIM 606286
UniProt Q9NXZ2  
 DDX43 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DDX43
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 TAS
    RNA helicase activity GO:0003724 IBA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    chromatin looping GO:0140588 IEA
 Experiment description of studies that identified DDX43 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DDX43
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 HNRNPH1 3187
Co-fractionation Homo sapiens
3 DHX15 1665
Co-fractionation Homo sapiens
4 KHDRBS2  
Co-fractionation Homo sapiens
5 HNRNPH3 3189
Co-fractionation Homo sapiens
6 DDX53  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KRTAP10-3  
Two-hybrid Homo sapiens
8 GORASP2 26003
Co-fractionation Homo sapiens
9 HDLBP 3069
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which DDX43 is involved
No pathways found





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