Gene description for MEGF8
Gene name multiple EGF-like-domains 8
Gene symbol MEGF8
Other names/aliases C19orf49
CRPT2
EGFL4
SBP1
Species Homo sapiens
 Database cross references - MEGF8
ExoCarta ExoCarta_1954
Entrez Gene 1954
HGNC 3233
MIM 604267
UniProt Q7Z7M0  
 MEGF8 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MEGF8
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    embryonic limb morphogenesis GO:0030326 ISS
    craniofacial suture morphogenesis GO:0097094 IMP
    determination of heart left/right asymmetry GO:0061371 IMP
    left/right pattern formation GO:0060972 IMP
    embryonic heart tube morphogenesis GO:0003143 ISS
    epiboly involved in gastrulation with mouth forming second GO:0055113 IMP
    BMP signaling pathway GO:0030509 ISS
    fasciculation of sensory neuron axon GO:0097155 ISS
    cell migration involved in gastrulation GO:0042074 IMP
    positive regulation of axon extension involved in axon guidance GO:0048842 ISS
    embryonic skeletal system morphogenesis GO:0048704 ISS
    determination of digestive tract left/right asymmetry GO:0071907 ISS
    regulation of gene expression GO:0010468 ISS
    limb morphogenesis GO:0035108 IMP
    embryonic heart tube left/right pattern formation GO:0060971 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of membrane GO:0016021 IEA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified MEGF8 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MEGF8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MEGF8 is involved
No pathways found





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