Gene description for HAPLN3
Gene name hyaluronan and proteoglycan link protein 3
Gene symbol HAPLN3
Other names/aliases EXLD1
Species Homo sapiens
 Database cross references - HAPLN3
ExoCarta ExoCarta_145864
Entrez Gene 145864
HGNC 21446
UniProt Q96S86  
 HAPLN3 identified in exosomes derived from the following tissue/cell type
Breast milk 17641064    
 Gene ontology annotations for HAPLN3
Molecular Function
    hyaluronic acid binding GO:0005540 IEA
Biological Process
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular space GO:0005615 IDA
    proteinaceous extracellular matrix GO:0005578 IEA
 Experiment description of studies that identified HAPLN3 in exosomes
Experiment ID 48
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for HAPLN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HAPLN3 is involved
No pathways found

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