Gene description for DHX34
Gene name DEAH (Asp-Glu-Ala-His) box polypeptide 34
Gene symbol DHX34
Other names/aliases DDX34
HRH1
Species Homo sapiens
 Database cross references - DHX34
ExoCarta ExoCarta_9704
Vesiclepedia VP_9704
Entrez Gene 9704
HGNC 16719
MIM 615475
UniProt Q14147  
 DHX34 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for DHX34
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    RNA helicase activity GO:0003724 IEA
    helicase activity GO:0004386 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IMP
    protein-containing complex binding GO:0044877 IPI
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IBA
    nuclear-transcribed mRNA catabolic process GO:0000956 IMP
    chromatin remodeling GO:0006338 IEA
    positive regulation of phosphorylation GO:0042327 IMP
    chromatin looping GO:0140588 IEA
    negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:2000623 IMP
Subcellular Localization
    membrane GO:0016020 HDA
 Experiment description of studies that identified DHX34 in exosomes
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for DHX34
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 KIF3A 11127
Affinity Capture-MS Homo sapiens
4 FBXL6  
Affinity Capture-MS Homo sapiens
5 EXOC8 149371
Co-fractionation Homo sapiens
6 CSTF2T  
Affinity Capture-MS Homo sapiens
7 CDPF1  
Affinity Capture-MS Homo sapiens
8 DNAJA2 10294
Affinity Capture-MS Homo sapiens
9 ARG2  
Affinity Capture-MS Homo sapiens
10 S100A2 6273
Affinity Capture-MS Homo sapiens
11 DHX8 1659
Affinity Capture-MS Homo sapiens
12 Isy1 57905
Affinity Capture-MS Mus musculus
13 POLA2  
Two-hybrid Homo sapiens
14 MAPK6  
Affinity Capture-MS Homo sapiens
15 GSK3B 2932
Two-hybrid Homo sapiens
16 TRIM28 10155
Affinity Capture-MS Homo sapiens
17 Sept6  
Affinity Capture-MS Mus musculus
18 FAM172A  
Affinity Capture-MS Homo sapiens
19 USP24 23358
Affinity Capture-MS Homo sapiens
20 MB21D1  
Proximity Label-MS Homo sapiens
21 PTGES3 10728
Affinity Capture-MS Homo sapiens
22 TRMT2A 27037
Co-fractionation Homo sapiens
23 FBXO38 81545
Affinity Capture-MS Homo sapiens
24 RPS6KA6 27330
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DHX34 is involved
No pathways found





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