Gene description for ZFPM1
Gene name zinc finger protein, FOG family member 1
Gene symbol ZFPM1
Other names/aliases FOG
FOG1
ZC2HC11A
ZNF408
ZNF89A
Species Homo sapiens
 Database cross references - ZFPM1
ExoCarta ExoCarta_161882
Entrez Gene 161882
HGNC 19762
MIM 601950
UniProt Q8IX07  
 ZFPM1 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ZFPM1
Molecular Function
    RNA polymerase II activating transcription factor binding GO:0001102 IEA
    RNA polymerase II transcription factor binding GO:0001085 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    transcription factor binding GO:0008134 IPI
Biological Process
    platelet formation GO:0030220 IGI
    cardiac muscle tissue morphogenesis GO:0055008 ISS
    mitral valve formation GO:0003192 ISS
    T-helper cell lineage commitment GO:0002295 IC
    blood coagulation GO:0007596 TAS
    negative regulation of protein binding GO:0032091 ISS
    megakaryocyte development GO:0035855 IEA
    atrial septum morphogenesis GO:0060413 ISS
    negative regulation of mast cell differentiation GO:0060377 ISS
    definitive erythrocyte differentiation GO:0060318 IEA
    erythrocyte differentiation GO:0030218 ISS
    transcription, DNA-templated GO:0006351 IEA
    megakaryocyte differentiation GO:0030219 ISS
    transcriptional activation by promoter-enhancer looping GO:0071733 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    regulation of chemokine production GO:0032642 IEA
    heart development GO:0007507 IBA
    primitive erythrocyte differentiation GO:0060319 IEA
    embryonic hemopoiesis GO:0035162 ISS
    positive regulation of interferon-gamma biosynthetic process GO:0045078 IDA
    negative regulation of fat cell differentiation GO:0045599 ISS
    outflow tract morphogenesis GO:0003151 ISS
    tricuspid valve formation GO:0003195 ISS
    ventricular septum morphogenesis GO:0060412 ISS
    atrioventricular valve morphogenesis GO:0003181 ISS
    regulation of definitive erythrocyte differentiation GO:0010724 IMP
    negative regulation of interleukin-4 biosynthetic process GO:0045403 IDA
    granulocyte differentiation GO:0030851 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IEA
    transcription factor complex GO:0005667 IDA
    transcriptional repressor complex GO:0017053 IDA
 Experiment description of studies that identified ZFPM1 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZFPM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TOP3B  
Two-hybrid Homo sapiens
2 GIPC1 10755
Two-hybrid Homo sapiens
3 GATA2  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which ZFPM1 is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome





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