Gene description for MYOC
Gene name myocilin, trabecular meshwork inducible glucocorticoid response
Gene symbol MYOC
Other names/aliases GLC1A
GPOA
JOAG
JOAG1
TIGR
myocilin
Species Homo sapiens
 Database cross references - MYOC
ExoCarta ExoCarta_4653
Entrez Gene 4653
HGNC 7610
MIM 601652
UniProt Q99972  
 MYOC identified in exosomes derived from the following tissue/cell type
Aqueous humor 21362503    
Tabecular meshwork cells 21362503    
 Gene ontology annotations for MYOC
Molecular Function
    protein binding GO:0005515 IPI
    frizzled binding GO:0005109 IPI
    receptor tyrosine kinase binding GO:0030971 IEA
    fibronectin binding GO:0001968 IPI
    myosin light chain binding GO:0032027 IPI
Biological Process
    myelination in peripheral nervous system GO:0022011 ISS
    positive regulation of mitochondrial depolarization GO:0051901 IDA
    non-canonical Wnt signaling pathway via JNK cascade GO:0038031 IMP
    bone development GO:0060348 ISS
    regulation of MAPK cascade GO:0043408 IDA
    clustering of voltage-gated sodium channels GO:0045162 ISS
    ERBB2-ERBB3 signaling pathway GO:0038133 ISS
    positive regulation of cell migration GO:0030335 IDA
    negative regulation of Rho protein signal transduction GO:0035024 IDA
    osteoblast differentiation GO:0001649 IDA
    skeletal muscle hypertrophy GO:0014734 ISS
    positive regulation of focal adhesion assembly GO:0051894 IDA
    negative regulation of cell-matrix adhesion GO:0001953 IDA
    negative regulation of stress fiber assembly GO:0051497 IDA
    positive regulation of stress fiber assembly GO:0051496 IDA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IDA
    positive regulation of protein kinase B signaling GO:0051897 IDA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA
    neuron projection development GO:0031175 IMP
Subcellular Localization
    node of Ranvier GO:0033268 ISS
    extracellular matrix GO:0031012 IDA
    endoplasmic reticulum GO:0005783 ISS
    Golgi apparatus GO:0005794 IDA
    cilium GO:0005929 IEA
    mitochondrial intermembrane space GO:0005758 IDA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    cytoplasmic vesicle GO:0031410 IDA
    mitochondrial outer membrane GO:0005741 IDA
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    rough endoplasmic reticulum GO:0005791 IEA
    mitochondrial inner membrane GO:0005743 IDA
 Experiment description of studies that identified MYOC in exosomes
1
Experiment ID 120
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21362503    
Organism Homo sapiens
Experiment description Protein profile of exosomes from trabecular meshwork cells.
Authors Stamer WD, Hoffman EA, Luther JM, Hachey DL, Schey KL.
Journal name JOP
Publication year 2011
Sample Aqueous humor
Sample name Aqueous humor - Normal
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
2
Experiment ID 118
ISEV standards
EV Biophysical techniques
SDCBP|GAPDH
EV Cytosolic markers
CD9|CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21362503    
Organism Homo sapiens
Experiment description Protein profile of exosomes from trabecular meshwork cells.
Authors Stamer WD, Hoffman EA, Luther JM, Hachey DL, Schey KL.
Journal name JOP
Publication year 2011
Sample Tabecular meshwork cells
Sample name Tabecular meshwork cells
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.07-1.2 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MYOC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FN1 2335
Invitro Homo sapiens
2 FBN1 2200
Reconstituted Complex Homo sapiens
3 OLFM3  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
4 MYL2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYOC is involved
No pathways found





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