Gene description for MYOC
Gene name myocilin, trabecular meshwork inducible glucocorticoid response
Gene symbol MYOC
Other names/aliases GLC1A
GPOA
JOAG
JOAG1
TIGR
myocilin
Species Homo sapiens
 Database cross references - MYOC
ExoCarta ExoCarta_4653
Vesiclepedia VP_4653
Entrez Gene 4653
HGNC 7610
MIM 601652
UniProt Q99972  
 MYOC identified in exosomes derived from the following tissue/cell type
Aqueous humor 21362503    
Tabecular meshwork cells 21362503    
 Gene ontology annotations for MYOC
Molecular Function
    fibronectin binding GO:0001968 IPI
    frizzled binding GO:0005109 IPI
    protein binding GO:0005515 IPI
    receptor tyrosine kinase binding GO:0030971 IEA
    myosin light chain binding GO:0032027 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    osteoblast differentiation GO:0001649 IBA
    osteoblast differentiation GO:0001649 IDA
    negative regulation of cell-matrix adhesion GO:0001953 IDA
    signal transduction GO:0007165 IBA
    skeletal muscle hypertrophy GO:0014734 ISS
    myelination in peripheral nervous system GO:0022011 ISS
    positive regulation of cell migration GO:0030335 IDA
    neuron projection development GO:0031175 IMP
    negative regulation of Rho protein signal transduction GO:0035024 IDA
    non-canonical Wnt signaling pathway GO:0035567 IMP
    ERBB2-ERBB3 signaling pathway GO:0038133 ISS
    regulation of MAPK cascade GO:0043408 IDA
    clustering of voltage-gated sodium channels GO:0045162 ISS
    positive regulation of JNK cascade GO:0046330 IMP
    positive regulation of stress fiber assembly GO:0051496 IDA
    negative regulation of stress fiber assembly GO:0051497 IDA
    positive regulation of focal adhesion assembly GO:0051894 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    positive regulation of mitochondrial depolarization GO:0051901 IDA
    bone development GO:0060348 ISS
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial intermembrane space GO:0005758 IDA
    endoplasmic reticulum GO:0005783 ISS
    rough endoplasmic reticulum GO:0005791 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cilium GO:0005929 IEA
    cytoplasmic vesicle GO:0031410 IDA
    node of Ranvier GO:0033268 ISS
    collagen-containing extracellular matrix GO:0062023 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified MYOC in exosomes
1
Experiment ID 120
MISEV standards
Biophysical techniques
GAPDH|CD9|CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21362503    
Organism Homo sapiens
Experiment description Protein profile of exosomes from trabecular meshwork cells.
Authors "Stamer WD, Hoffman EA, Luther JM, Hachey DL, Schey KL."
Journal name JOP
Publication year 2011
Sample Aqueous humor
Sample name Aqueous humor - Normal
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
2
Experiment ID 118
MISEV standards
Biophysical techniques
SDCBP|GAPDH|CD9|CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21362503    
Organism Homo sapiens
Experiment description Protein profile of exosomes from trabecular meshwork cells.
Authors "Stamer WD, Hoffman EA, Luther JM, Hachey DL, Schey KL."
Journal name JOP
Publication year 2011
Sample Tabecular meshwork cells
Sample name Tabecular meshwork cells
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.07-1.2 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MYOC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ECE1 1889
Two-hybrid Homo sapiens
2 FTL 2512
Two-hybrid Homo sapiens
3 FBN1 2200
Reconstituted Complex Homo sapiens
4 CLIC1 1192
Two-hybrid Homo sapiens
5 TIMP1 7076
Two-hybrid Homo sapiens
6 HAGH 3029
Two-hybrid Homo sapiens
7 EEF1A1 1915
Two-hybrid Homo sapiens
8 CKM  
Two-hybrid Homo sapiens
9 NOTCH2 4853
Two-hybrid Homo sapiens
10 PKM 5315
Two-hybrid Homo sapiens
11 ACTA2 59
Two-hybrid Homo sapiens
12 CAP1 10487
Far Western Homo sapiens
13 LGALS3 3958
Two-hybrid Homo sapiens
14 IGKC 3514
Affinity Capture-MS Homo sapiens
15 MYOC 4653
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
16 TNFRSF1A 7132
Two-hybrid Homo sapiens
17 TKT 7086
Far Western Homo sapiens
18 OLFML3 56944
Two-hybrid Homo sapiens
19 ENO1 2023
Far Western Homo sapiens
20 A2M 2
Two-hybrid Homo sapiens
21 FN1 2335
Reconstituted Complex Homo sapiens
22 RFC1 5981
Two-hybrid Homo sapiens
23 TGFBR1 7046
Two-hybrid Homo sapiens
24 HSPA4 3308
Affinity Capture-MS Homo sapiens
25 COL1A2 1278
Two-hybrid Homo sapiens
26 TPM1 7168
Affinity Capture-MS Homo sapiens
27 C1QB 713
Two-hybrid Homo sapiens
28 ITGA7 3679
Two-hybrid Homo sapiens
29 GAPDH 2597
Two-hybrid Homo sapiens
Far Western Homo sapiens
30 SERPINF1 5176
Two-hybrid Homo sapiens
31 FUBP1 8880
Two-hybrid Homo sapiens
32 KIF23 9493
Affinity Capture-MS Homo sapiens
33 LAMA5 3911
Two-hybrid Homo sapiens
34 IGLL1  
Two-hybrid Homo sapiens
35 CD81 975
Two-hybrid Homo sapiens
36 ALDOA 226
Far Western Homo sapiens
37 COL3A1 1281
Two-hybrid Homo sapiens
38 ACTB 60
Two-hybrid Homo sapiens
39 MYH11 4629
Affinity Capture-MS Homo sapiens
40 ANXA2 302
Far Western Homo sapiens
41 OLFM3  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
42 VIM 7431
Affinity Capture-MS Homo sapiens
43 ACTG1 71
Two-hybrid Homo sapiens
44 MAEA 10296
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MYOC is involved
No pathways found





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