Gene description for Ppp2cb
Gene name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Gene symbol Ppp2cb
Other names/aliases AI115466
D8Ertd766e
PP2Ac
Species Mus musculus
 Database cross references - Ppp2cb
ExoCarta ExoCarta_19053
Entrez Gene 19053
UniProt P62715  
 Ppp2cb identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Ppp2cb
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    hydrolase activity GO:0016787 IEA
    protein C-terminus binding GO:0008022 ISO
    phosphoprotein phosphatase activity GO:0004721 ISO
    protein serine/threonine phosphatase activity GO:0004722 ISO
Biological Process
    response to antibiotic GO:0046677 IMP
    response to hydrogen peroxide GO:0042542 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    negative regulation of Ras protein signal transduction GO:0046580 ISO
    regulation of gene expression GO:0010468 IMP
    apoptotic mitochondrial changes GO:0008637 IMP
    protein dephosphorylation GO:0006470 ISO
    response to endoplasmic reticulum stress GO:0034976 IMP
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 IDA
    protein phosphatase type 2A complex GO:0000159 IDA
    chromosome, centromeric region GO:0000775 IEA
    chromosome GO:0005694 IEA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified Ppp2cb in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ppp2cb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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