Gene description for NAB1
Gene name NGFI-A binding protein 1 (EGR1 binding protein 1)
Gene symbol NAB1
Other names/aliases -
Species Homo sapiens
 Database cross references - NAB1
ExoCarta ExoCarta_4664
Vesiclepedia VP_4664
Entrez Gene 4664
HGNC 7626
MIM 600800
UniProt Q13506  
 NAB1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NAB1
Molecular Function
    transcription coregulator activity GO:0003712 IBA
Biological Process
    endochondral ossification GO:0001958 IEA
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 NAS
    Schwann cell differentiation GO:0014037 IEA
    myelination GO:0042552 IEA
    regulation of epidermis development GO:0045682 IEA
    negative regulation of DNA-templated transcription GO:0045892 NAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified NAB1 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NAB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
3 NXF1 10482
Affinity Capture-RNA Homo sapiens
4 CENPJ 55835
Affinity Capture-MS Homo sapiens
5 MVK 4598
Affinity Capture-MS Homo sapiens
6 ENO1 2023
Affinity Capture-RNA Homo sapiens
7 KRAS 3845
Synthetic Growth Defect Homo sapiens
8 POU2AF1  
Two-hybrid Homo sapiens
9 CEBPA  
Proximity Label-MS Homo sapiens
10 AKTIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PRICKLE4  
Affinity Capture-MS Homo sapiens
12 Mkln1  
Affinity Capture-MS Mus musculus
13 MOV10 4343
Affinity Capture-RNA Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 CHD4 1108
Affinity Capture-Western Homo sapiens
16 NAB2 4665
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 Racgap1 26934
Affinity Capture-MS Mus musculus
18 EGR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
19 SHMT2 6472
Affinity Capture-RNA Homo sapiens
20 METTL21B  
Affinity Capture-MS Homo sapiens
21 SLX4  
Affinity Capture-MS Homo sapiens
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