Gene description for C6
Gene name complement component 6
Gene symbol C6
Other names/aliases -
Species Homo sapiens
 Database cross references - C6
ExoCarta ExoCarta_729
Entrez Gene 729
HGNC 1339
MIM 217050
UniProt P13671  
 C6 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for C6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    complement activation, classical pathway GO:0006958 IEA
    complement activation GO:0006956 TAS
    positive regulation of activation of membrane attack complex GO:0001970 IEA
    innate immune response GO:0045087 TAS
    cytolysis GO:0019835 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    in utero embryonic development GO:0001701 IEA
    regulation of complement activation GO:0030449 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 TAS
    membrane attack complex GO:0005579 IEA
 Experiment description of studies that identified C6 in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C5 727
Invitro Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
2 F2 2147
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which C6 is involved
PathwayEvidenceSource
Regulation of Complement cascade TAS Reactome
Terminal pathway of complement TAS Reactome





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