Gene description for PDZRN3
Gene name PDZ domain containing ring finger 3
Gene symbol PDZRN3
Other names/aliases LNX3
SEMACAP3
SEMCAP3
Species Homo sapiens
 Database cross references - PDZRN3
ExoCarta ExoCarta_23024
Vesiclepedia VP_23024
Entrez Gene 23024
HGNC 17704
MIM 609729
UniProt Q9UPQ7  
 PDZRN3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PDZRN3
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISS
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    neuromuscular junction development GO:0007528 IBA
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    neuromuscular junction GO:0031594 IBA
 Experiment description of studies that identified PDZRN3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDZRN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 KRT18 3875
Proximity Label-MS Homo sapiens
3 CCDC96  
Affinity Capture-MS Homo sapiens
4 HOOK1  
Proximity Label-MS Homo sapiens
5 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LNX2  
Two-hybrid Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
8 LRRC59 55379
Cross-Linking-MS (XL-MS) Homo sapiens
9 SDHA 6389
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 FZD4 8322
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
11 TRIM52  
Affinity Capture-MS Homo sapiens
12 KRT8 3856
Proximity Label-MS Homo sapiens
13 TBX20 57057
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 CUL3 8452
Affinity Capture-MS Homo sapiens
15 RBM12B  
Affinity Capture-MS Homo sapiens
16 FAM13C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ANKRD20A2  
Affinity Capture-MS Homo sapiens
18 TAF1  
Affinity Capture-MS Homo sapiens
19 DUSP16  
Affinity Capture-MS Homo sapiens
20 Dlg4  
Two-hybrid Rattus norvegicus
21 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PPCS 79717
Affinity Capture-MS Homo sapiens
23 UBE2D2 7322
Reconstituted Complex Homo sapiens
24 MUSK  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NIN 51199
Proximity Label-MS Homo sapiens
27 BRD1 23774
Affinity Capture-MS Homo sapiens
28 ANKRD20A1  
Affinity Capture-MS Homo sapiens
29 PCM1 5108
Proximity Label-MS Homo sapiens
30 OIP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 Dvl3  
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
Co-fractionation Mus musculus
33 LURAP1  
Affinity Capture-MS Homo sapiens
34 LNX1  
Two-hybrid Homo sapiens
35 POTEB3 102724631
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PDZRN3 is involved
No pathways found





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