Gene description for FZD4
Gene name	frizzled class receptor 4
Gene symbol	FZD4
Other names/aliases	CD344 EVR1 FEVR FZD4S Fz-4 Fz4 FzE4 GPCR hFz4
Species	Homo sapiens
Database cross references - FZD4
ExoCarta	ExoCarta_8322
Vesiclepedia	VP_8322
Entrez Gene	8322
HGNC	4042
MIM	604579
UniProt	Q9ULV1
FZD4 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for FZD4

Molecular Function     amyloid-beta binding GO:0001540 IPI     cytokine receptor activity GO:0004896 IDA     G protein-coupled receptor activity GO:0004930 IEA     protein binding GO:0005515 IPI     Wnt-protein binding GO:0017147 IBA     Wnt-protein binding GO:0017147 TAS     cytokine binding GO:0019955 IPI     PDZ domain binding GO:0030165 IDA     PDZ domain binding GO:0030165 IPI     ubiquitin protein ligase binding GO:0031625 IPI     signaling receptor activity GO:0038023 ISS     protein homodimerization activity GO:0042803 IPI     Wnt receptor activity GO:0042813 IBA     Wnt receptor activity GO:0042813 IDA     protein-containing complex binding GO:0044877 IPI     protein heterodimerization activity GO:0046982 IPI Biological Process     angiogenesis GO:0001525 IEA     vasculogenesis GO:0001570 IEA     response to hypoxia GO:0001666 IEA     G protein-coupled receptor signaling pathway GO:0007186 IEA     Wnt signaling pathway, calcium modulating pathway GO:0007223 IDA     sensory perception of sound GO:0007605 IEA     cell population proliferation GO:0008283 IEA     negative regulation of cell-substrate adhesion GO:0010812 IMP     Wnt signaling pathway GO:0016055 ISS     cytokine-mediated signaling pathway GO:0019221 IEA     neuron differentiation GO:0030182 ISS     positive regulation of cell migration GO:0030335 IMP     regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 IEA     locomotion involved in locomotory behavior GO:0031987 IEA     substrate adhesion-dependent cell spreading GO:0034446 IEA     extracellular matrix-cell signaling GO:0035426 IEA     non-canonical Wnt signaling pathway GO:0035567 IBA     non-canonical Wnt signaling pathway GO:0035567 TAS     progesterone secretion GO:0042701 IEA     endothelial cell differentiation GO:0045446 IEA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of dendrite morphogenesis GO:0050775 IEA     positive regulation of DNA-binding transcription factor activity GO:0051091 IDA     canonical Wnt signaling pathway GO:0060070 IBA     canonical Wnt signaling pathway GO:0060070 IDA     canonical Wnt signaling pathway GO:0060070 TAS     establishment of blood-brain barrier GO:0060856 IEA     retina vasculature morphogenesis in camera-type eye GO:0061299 IBA     retina vasculature morphogenesis in camera-type eye GO:0061299 IMP     cerebellum vasculature morphogenesis GO:0061301 IEA     retinal blood vessel morphogenesis GO:0061304 IEA     cellular response to retinoic acid GO:0071300 ISS     Norrin signaling pathway GO:0110135 IDA     positive regulation of neuron projection arborization GO:0150012 ISS     cellular response to leukemia inhibitory factor GO:1990830 IEA Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IC     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     cell-cell junction GO:0005911 IEA     cell surface GO:0009986 IDA     dendrite GO:0030425 ISS     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     glutamatergic synapse GO:0098978 IEA