Gene description for Morf4l1
Gene name mortality factor 4 like 1
Gene symbol Morf4l1
Other names/aliases MORFRG15
MRG15
TEG-189
Tex189
mKIAA4002
Species Mus musculus
 Database cross references - Morf4l1
ExoCarta ExoCarta_21761
Vesiclepedia VP_21761
Entrez Gene 21761
UniProt P60762  
 Morf4l1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Morf4l1
Molecular Function
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
Biological Process
    double-strand break repair via homologous recombination GO:0000724 ISO
    double-strand break repair via homologous recombination GO:0000724 ISS
    chromatin remodeling GO:0006338 TAS
    cell population proliferation GO:0008283 IMP
    regulation of apoptotic process GO:0042981 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    fibroblast proliferation GO:0048144 IMP
    regulation of cell cycle GO:0051726 ISO
    positive regulation of double-strand break repair via homologous recombination GO:1905168 ISO
    regulation of double-strand break repair GO:2000779 NAS
Subcellular Localization
    nucleosome GO:0000786 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    NuA4 histone acetyltransferase complex GO:0035267 IBA
    NuA4 histone acetyltransferase complex GO:0035267 ISO
    NuA4 histone acetyltransferase complex GO:0035267 ISS
    Sin3-type complex GO:0070822 ISO
    Sin3-type complex GO:0070822 ISS
 Experiment description of studies that identified Morf4l1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Morf4l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Vezf1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
2 Rnf2  
Affinity Capture-MS Mus musculus
3 Ubc  
Affinity Capture-Western Mus musculus
4 PFN2 5217
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 Fmr1  
Affinity Capture-MS Mus musculus
6 TLE1 7088
Affinity Capture-Western Homo sapiens
7 Rb1  
Affinity Capture-Western Mus musculus
8 SIN3A  
Affinity Capture-Western Homo sapiens
9 Nanog  
Affinity Capture-MS Mus musculus
10 Kdm5b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
11 MRFAP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 Hist2h2be  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Morf4l1 is involved
No pathways found





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