Gene description for Morf4l1
Gene name mortality factor 4 like 1
Gene symbol Morf4l1
Other names/aliases MORFRG15
MRG15
TEG-189
Tex189
mKIAA4002
Species Mus musculus
 Database cross references - Morf4l1
ExoCarta ExoCarta_21761
Entrez Gene 21761
UniProt P60762  
 Morf4l1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Morf4l1
Molecular Function
    protein N-terminus binding GO:0047485 ISO
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
Biological Process
    histone deacetylation GO:0016575 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    DNA repair GO:0006281 IEA
    cellular response to DNA damage stimulus GO:0006974 IEA
    cell proliferation GO:0008283 IMP
    chromatin remodeling GO:0006338 TAS
    histone H4 acetylation GO:0043967 ISO
    transcription, DNA-templated GO:0006351 IEA
    double-strand break repair via homologous recombination GO:0000724 ISO
    chromatin modification GO:0016568 IEA
    DNA recombination GO:0006310 IEA
    regulation of growth GO:0040008 IEA
    histone H2A acetylation GO:0043968 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    NuA4 histone acetyltransferase complex GO:0035267 ISO
    nucleoplasm GO:0005654 ISO
    Sin3 complex GO:0016580 ISO
 Experiment description of studies that identified Morf4l1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Morf4l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIN3A  
Affinity Capture-Western Homo sapiens
2 TLE1  
Affinity Capture-Western Homo sapiens
3 PFN2 5217
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which Morf4l1 is involved
PathwayEvidenceSource
HATs acetylate histones IEA Reactome





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