Gene description for BPI
Gene name bactericidal/permeability-increasing protein
Gene symbol BPI
Other names/aliases BPIFD1
rBPI
Species Homo sapiens
 Database cross references - BPI
ExoCarta ExoCarta_671
Vesiclepedia VP_671
Entrez Gene 671
HGNC 1095
MIM 109195
UniProt P17213  
 BPI identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for BPI
Molecular Function
    lipopolysaccharide binding GO:0001530 IDA
Biological Process
    negative regulation of tumor necrosis factor production GO:0032720 IDA
    negative regulation of interleukin-8 production GO:0032717 IDA
    negative regulation of interleukin-6 production GO:0032715 IDA
    defense response to Gram-negative bacterium GO:0050829 IEA
    immune response GO:0006955 IEA
    negative regulation of macrophage activation GO:0043031 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    integral component of plasma membrane GO:0005887 TAS
    cytoplasm GO:0005737 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified BPI in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BPI
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which BPI is involved
No pathways found





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