Gene description for Nes
Gene name nestin
Gene symbol Nes
Other names/aliases AA166324
C78523
ESTM46
Species Mus musculus
 Database cross references - Nes
ExoCarta ExoCarta_18008
Vesiclepedia VP_18008
Entrez Gene 18008
UniProt Q6P5H2  
 Nes identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Nes
Molecular Function
    protein binding GO:0005515 IPI
    intermediate filament binding GO:0019215 ISS
    CCR5 chemokine receptor binding GO:0031730 IBA
    CCR5 chemokine receptor binding GO:0031730 ISO
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 IEA
    G2/M transition of mitotic cell cycle GO:0000086 ISO
    nervous system development GO:0007399 IDA
    brain development GO:0007420 ISS
    positive regulation of intermediate filament depolymerization GO:0030844 IBA
    positive regulation of intermediate filament depolymerization GO:0030844 ISO
    positive regulation of intermediate filament depolymerization GO:0030844 ISS
    embryonic camera-type eye development GO:0031076 ISS
    negative regulation of protein binding GO:0032091 ISO
    negative regulation of catalytic activity GO:0043086 ISO
    negative regulation of neuron apoptotic process GO:0043524 IMP
    cell projection morphogenesis GO:0048858 IMP
    neuron apoptotic process GO:0051402 IMP
    stem cell proliferation GO:0072089 IEA
    stem cell proliferation GO:0072089 ISO
    positive regulation of neural precursor cell proliferation GO:2000179 ISO
    positive regulation of neural precursor cell proliferation GO:2000179 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    intermediate filament GO:0005882 IBA
    intermediate filament GO:0005882 IDA
    intermediate filament GO:0005882 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
 Experiment description of studies that identified Nes in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nes
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Mettl21e  
Affinity Capture-MS Mus musculus
3 Tnik  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Usp40  
Affinity Capture-Western Mus musculus
6 Mycbp2 105689
Affinity Capture-MS Mus musculus
7 Tfe3  
Affinity Capture-MS Mus musculus
8 Shank3  
Affinity Capture-MS Mus musculus
9 Huwe1  
Affinity Capture-MS Mus musculus
10 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Nes is involved
No pathways found





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