Gene description for Thrap3
Gene name thyroid hormone receptor associated protein 3
Gene symbol Thrap3
Other names/aliases 9330151F09Rik
B230333E16Rik
Trap150
Species Mus musculus
 Database cross references - Thrap3
ExoCarta ExoCarta_230753
Entrez Gene 230753
UniProt Q569Z6  
 Thrap3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Thrap3
Molecular Function
    receptor activity GO:0004872 ISO
    transcription coactivator activity GO:0003713 ISO
    core promoter sequence-specific DNA binding GO:0001046 IDA
    transcription cofactor activity GO:0003712 ISO
    thyroid hormone receptor binding GO:0046966 ISO
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    RNA polymerase II transcription cofactor activity GO:0001104 ISO
    nucleotide binding GO:0000166 IEA
    phosphoprotein binding GO:0051219 ISO
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    nuclear-transcribed mRNA catabolic process GO:0000956 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    regulation of nucleic acid-templated transcription GO:1903506 IMP
    mRNA processing GO:0006397 IEA
    rhythmic process GO:0048511 IEA
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    transcription, DNA-templated GO:0006351 IEA
    transcription from RNA polymerase II promoter GO:0006366 IC
    positive regulation of circadian rhythm GO:0042753 ISO
    intracellular steroid hormone receptor signaling pathway GO:0030518 ISO
    positive regulation of mRNA splicing, via spliceosome GO:0048026 ISO
    mRNA stabilization GO:0048255 ISO
    RNA splicing GO:0008380 IEA
    transcription initiation from RNA polymerase II promoter GO:0006367 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISO
    androgen receptor signaling pathway GO:0030521 ISO
Subcellular Localization
    exon-exon junction complex GO:0035145 ISO
    mediator complex GO:0016592 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Thrap3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Thrap3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Thrap3 is involved
No pathways found





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