Gene description for Carm1
Gene name coactivator-associated arginine methyltransferase 1
Gene symbol Carm1
Other names/aliases Prmt4
Species Mus musculus
 Database cross references - Carm1
ExoCarta ExoCarta_59035
Vesiclepedia VP_59035
Entrez Gene 59035
UniProt Q9WVG6  
 Carm1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Carm1
Molecular Function
    methyltransferase activity GO:0008168 IEA
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    transferase activity GO:0016740 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    P-methyltransferase activity GO:0051994 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    mRNA methyltransferase activity GO:0008174 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    RNA methyltransferase activity GO:0008173 IEA
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    protein-arginine N-methyltransferase activity GO:0016274 ISO
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    histone methyltransferase activity (H3-R17 specific) GO:0035642 IDA
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    DNA-methyltransferase activity GO:0009008 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    protein-lysine N-methyltransferase activity GO:0016279 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    transcription regulatory region DNA binding GO:0044212 IMP
    lysine-acetylated histone binding GO:0070577 IDA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    Se-methyltransferase activity GO:0051995 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 IDA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    protein homodimerization activity GO:0042803 IPI
    monomethylamine methyltransferase activity GO:0043852 IEA
    protein-arginine omega-N asymmetric methyltransferase activity GO:0035242 IDA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    protein methyltransferase activity GO:0008276 IDA
    lysine N-methyltransferase activity GO:0016278 IEA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    histone-arginine N-methyltransferase activity GO:0008469 ISO
    tRNA methyltransferase activity GO:0008175 IEA
    rRNA methyltransferase activity GO:0008649 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    histone methyltransferase activity GO:0042054 ISO
    transcription coactivator activity GO:0003713 IDA
    trimethylamine methyltransferase activity GO:0043834 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    N-methyltransferase activity GO:0008170 IEA
    O-methyltransferase activity GO:0008171 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    C-methyltransferase activity GO:0008169 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    protein binding GO:0005515 IPI
    S-methyltransferase activity GO:0008172 IEA
Biological Process
    histone methylation GO:0016571 ISO
    endochondral bone morphogenesis GO:0060350 IMP
    histone H3-R2 methylation GO:0034970 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    intracellular steroid hormone receptor signaling pathway GO:0030518 IDA
    peptidyl-arginine N-methylation GO:0035246 ISO
    regulation of growth plate cartilage chondrocyte proliferation GO:0003420 IMP
    protein methylation GO:0006479 IMP
    intracellular estrogen receptor signaling pathway GO:0030520 IGI
    regulation of mRNA binding GO:1902415 ISO
    positive regulation of fat cell differentiation GO:0045600 IMP
    regulation of transcription, DNA-templated GO:0006355 IDA
    regulation of intracellular estrogen receptor signaling pathway GO:0033146 IDA
    negative regulation of dendrite development GO:2000171 ISO
    histone H3-R17 methylation GO:0034971 IDA
    chromatin modification GO:0016568 IEA
    histone arginine methylation GO:0034969 IDA
    negative regulation of protein binding GO:0032091 IDA
    pathogenesis GO:0009405 IEA
    response to cAMP GO:0051591 ISO
    methylation GO:0032259 IEA
    transcription, DNA-templated GO:0006351 IEA
    peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0019919 IDA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    cytosol GO:0005829 IDA
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Carm1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Carm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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