Gene description for Gnb2l1
Gene name guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
Gene symbol Gnb2l1
Other names/aliases AL033335
GB-like
Gnb2-rs1
Rack1
p205
Species Mus musculus
 Database cross references - Gnb2l1
ExoCarta ExoCarta_14694
Entrez Gene 14694
UniProt P68040  
 Gnb2l1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
Pancreatic cells 19351151    
 Gene ontology annotations for Gnb2l1
Molecular Function
    receptor activity GO:0004872 ISA
    receptor tyrosine kinase binding GO:0030971 ISO
    poly(A) RNA binding GO:0044822 ISO
    protein phosphatase binding GO:0019903 ISO
    cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 ISO
    enzyme binding GO:0019899 ISO
    ion channel inhibitor activity GO:0008200 IDA
    protein kinase C binding GO:0005080 ISO
    SH2 domain binding GO:0042169 ISO
    protein homodimerization activity GO:0042803 ISO
    protein binding GO:0005515 IPI
    signaling adaptor activity GO:0035591 ISO
    protein tyrosine kinase inhibitor activity GO:0030292 ISO
Biological Process
    positive regulation of GTPase activity GO:0043547 ISO
    protein localization GO:0008104 ISA
    positive regulation of protein phosphorylation GO:0001934 ISO
    cell cycle GO:0007049 IEA
    negative regulation of translation GO:0017148 ISO
    negative regulation of cell growth GO:0030308 ISO
    rhythmic process GO:0048511 IEA
    negative regulation of gene expression GO:0010629 ISO
    apoptotic process GO:0006915 IEA
    regulation of translation GO:0006417 IEA
    positive regulation of apoptotic process GO:0043065 ISO
    regulation of cell cycle GO:0051726 ISO
    gastrulation GO:0007369 IEA
    positive regulation of protein homooligomerization GO:0032464 ISO
    intracellular signal transduction GO:0035556 ISA
    positive regulation of cAMP catabolic process GO:0030822 ISO
    negative regulation of hydrogen peroxide-induced neuron death GO:1903208 ISO
    negative regulation of protein kinase B signaling GO:0051898 ISO
    regulation of growth GO:0040008 IEA
    osteoblast differentiation GO:0001649 ISO
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
    negative regulation of phagocytosis GO:0050765 ISO
    negative regulation of peptidyl-serine phosphorylation GO:0033137 ISO
    positive regulation of mitochondrial depolarization GO:0051901 ISO
    positive regulation of cell migration GO:0030335 ISO
    multicellular organismal development GO:0007275 IEA
    regulation of establishment of protein localization to plasma membrane GO:0090003 ISO
    positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 ISO
    negative regulation of protein tyrosine kinase activity GO:0061099 ISO
    cellular response to glucose stimulus GO:0071333 ISO
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISO
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 ISO
    small ribosomal subunit GO:0015935 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    phagocytic cup GO:0001891 ISO
    extracellular exosome GO:0070062 ISO
    midbody GO:0030496 ISO
    cell body GO:0044297 IDA
    cytoskeleton GO:0005856 IEA
    mitochondrion GO:0005739 ISO
    neuron projection GO:0043005 IDA
    intracellular GO:0005622 ISA
    IRE1-RACK1-PP2A complex GO:1990630 ISO
    dendrite GO:0030425 IDA
    neuronal cell body GO:0043025 IDA
    cytosol GO:0005829 ISO
    cell projection GO:0042995 IEA
 Experiment description of studies that identified Gnb2l1 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gnb2l1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gnb2l1 is involved
No pathways found





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