Gene description for Tpt1
Gene name tumor protein, translationally-controlled 1
Gene symbol Tpt1
Other names/aliases TCTP
Trt
p21
p23
Species Mus musculus
 Database cross references - Tpt1
ExoCarta ExoCarta_22070
Entrez Gene 22070
UniProt P63028  
 Tpt1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tpt1
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IPI
Biological Process
    negative regulation of ectoderm development GO:2000384 IMP
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 ISO
    stem cell maintenance GO:0019827 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    extracellular space GO:0005615 ISO
    tubulin complex GO:0045298 ISO
    nucleus GO:0005634 ISO
    multivesicular body GO:0005771 ISO
    nucleoplasm GO:0005654 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Tpt1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tpt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tpt1 is involved
No pathways found





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