Gene description for Pgk2
Gene name phosphoglycerate kinase 2
Gene symbol Pgk2
Other names/aliases Pgk-2
Tcp-2
Species Mus musculus
 Database cross references - Pgk2
ExoCarta ExoCarta_18663
Vesiclepedia VP_18663
Entrez Gene 18663
UniProt P09041  
 Pgk2 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Pgk2
Molecular Function
    phosphoglycerate kinase activity GO:0004618 IBA
    phosphoglycerate kinase activity GO:0004618 IDA
    phosphoglycerate kinase activity GO:0004618 IMP
    phosphoglycerate kinase activity GO:0004618 ISO
    phosphoglycerate kinase activity GO:0004618 ISS
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 ISS
    ADP binding GO:0043531 IBA
Biological Process
    gluconeogenesis GO:0006094 IBA
    glycolytic process GO:0006096 IBA
    glycolytic process GO:0006096 IC
    glycolytic process GO:0006096 IEA
    glycolytic process GO:0006096 IMP
    flagellated sperm motility GO:0030317 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytosol GO:0005829 IBA
    cilium GO:0005929 IDA
    sperm fibrous sheath GO:0035686 IBA
    sperm fibrous sheath GO:0035686 IDA
 Experiment description of studies that identified Pgk2 in sEVs
1
Experiment ID 33
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Pgk2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps21 66481
Co-fractionation Mus musculus
2 Rps14 20044
Co-fractionation Mus musculus
3 Rpl3 27367
Co-fractionation Mus musculus
4 Atxn1  
Affinity Capture-MS Mus musculus
5 Rps5 20103
Co-fractionation Mus musculus
6 Rpl32 19951
Co-fractionation Mus musculus
7 Tpt1 22070
Co-fractionation Mus musculus
8 Actg1 11465
Co-fractionation Mus musculus
9 Rps15 20054
Co-fractionation Mus musculus
10 Rpl8 26961
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Pgk2 is involved
PathwayEvidenceSource
Gluconeogenesis IEA Reactome
Glucose metabolism IEA Reactome
Glycolysis IEA Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome





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