Gene description for Rps21
Gene name ribosomal protein S21
Gene symbol Rps21
Other names/aliases 1810049N11Rik
2410030A14Rik
Species Mus musculus
 Database cross references - Rps21
ExoCarta ExoCarta_66481
Vesiclepedia VP_66481
Entrez Gene 66481
UniProt Q9CQR2  
 Rps21 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Rps21
Molecular Function
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IDA
    structural constituent of ribosome GO:0003735 ISO
    ribosome binding GO:0043022 ISS
Biological Process
    endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000447 IBA
    endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000461 IBA
    cytoplasmic translation GO:0002181 ISO
    cytoplasmic translation GO:0002181 ISS
    cytoplasmic translation GO:0002181 NAS
Subcellular Localization
    cytoplasm GO:0005737 NAS
    rough endoplasmic reticulum GO:0005791 IEA
    cytosol GO:0005829 TAS
    ribosome GO:0005840 NAS
    cytosolic ribosome GO:0022626 ISO
    cytosolic small ribosomal subunit GO:0022627 IBA
    cytosolic small ribosomal subunit GO:0022627 IDA
    cytosolic small ribosomal subunit GO:0022627 ISO
    cytosolic small ribosomal subunit GO:0022627 ISS
    cytosolic small ribosomal subunit GO:0022627 NAS
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    postsynapse GO:0098794 NAS
 Experiment description of studies that identified Rps21 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rps21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps27a 78294
Co-fractionation Mus musculus
2 Rps3 27050
Co-fractionation Mus musculus
3 Rpl11 67025
Co-fractionation Mus musculus
4 Psmd8 57296
Co-fractionation Mus musculus
5 Rpl31 114641
Co-fractionation Mus musculus
6 Rps25 75617
Co-fractionation Mus musculus
7 Rps28 54127
Co-fractionation Mus musculus
8 Rps10 67097
Co-fractionation Mus musculus
9 Rpl13a 22121
Co-fractionation Mus musculus
10 Rps16 20055
Co-fractionation Mus musculus
11 Rpl15 66480
Co-fractionation Mus musculus
12 Rplp2 67186
Co-fractionation Mus musculus
13 Rps4x 20102
Co-fractionation Mus musculus
14 Rpl4 67891
Co-fractionation Mus musculus
15 Rpl14 67115
Co-fractionation Mus musculus
16 Rps2 16898
Co-fractionation Mus musculus
17 Rpl32 19951
Co-fractionation Mus musculus
18 Rps8 20116
Co-fractionation Mus musculus
19 Rps23 66475
Co-fractionation Mus musculus
20 Rpl7a 27176
Co-fractionation Mus musculus
21 Rps18 20084
Co-fractionation Mus musculus
22 Atxn1  
Proximity Label-MS Mus musculus
23 Rpl6 19988
Co-fractionation Mus musculus
24 Fzr1  
Affinity Capture-MS Mus musculus
25 Rps19 20085
Co-fractionation Mus musculus
26 Mthfd1 108156
Co-fractionation Mus musculus
27 Rpl9 20005
Co-fractionation Mus musculus
28 Rpl24 68193
Co-fractionation Mus musculus
29 Tpt1 22070
Co-fractionation Mus musculus
30 Rps6 20104
Co-fractionation Mus musculus
31 Rpl18a 76808
Co-fractionation Mus musculus
32 Rps24 20088
Co-fractionation Mus musculus
33 Rpl23 65019
Co-fractionation Mus musculus
34 Rps5 20103
Co-fractionation Mus musculus
35 Rps7 20115
Co-fractionation Mus musculus
36 Rpl22 19934
Co-fractionation Mus musculus
37 Psmd1 70247
Co-fractionation Mus musculus
38 Tmem173  
Proximity Label-MS Mus musculus
39 Rps20 67427
Co-fractionation Mus musculus
40 Eef2 13629
Co-fractionation Mus musculus
41 Rps11 27207
Co-fractionation Mus musculus
42 Rps13 68052
Co-fractionation Mus musculus
43 Rpl12 269261
Co-fractionation Mus musculus
44 Eef1a1 13627
Co-fractionation Mus musculus
45 Rps9 76846
Co-fractionation Mus musculus
46 Ddx3x 13205
Co-fractionation Mus musculus
47 Rpl7 19989
Co-fractionation Mus musculus
48 Rps15a 267019
Co-fractionation Mus musculus
49 Gnb2l1 14694
Co-fractionation Mus musculus
50 Rps15 20054
Co-fractionation Mus musculus
51 Pgk2 18663
Co-fractionation Mus musculus
52 Rps3a1 20091
Co-fractionation Mus musculus
53 Uchl5 56207
Co-fractionation Mus musculus
54 Rpl26 19941
Co-fractionation Mus musculus
55 Rps17 20068
Co-fractionation Mus musculus
56 Rps26 27370
Co-fractionation Mus musculus
57 Rpl23a 268449
Co-fractionation Mus musculus
58 Rps14 20044
Co-fractionation Mus musculus
59 Rpl30 19946
Co-fractionation Mus musculus
60 Rpl35 66489
Co-fractionation Mus musculus
61 Rps27 57294
Co-fractionation Mus musculus
62 Rpsa 16785
Co-fractionation Mus musculus
63 Eef1b2 55949
Co-fractionation Mus musculus
64 Rpl3 27367
Co-fractionation Mus musculus
65 Psmd11 69077
Co-fractionation Mus musculus
66 Rpl5 100503670
Co-fractionation Mus musculus
67 Otx2  
Affinity Capture-MS Mus musculus
68 Rpl13 270106
Co-fractionation Mus musculus
69 Rpl8 26961
Co-fractionation Mus musculus
70 Rps12 20042
Co-fractionation Mus musculus
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