Gene description for Snx6
Gene name sorting nexin 6
Gene symbol Snx6
Other names/aliases 2010006G21Rik
2610032J07Rik
2810425K19Rik
AU018928
C85963
Species Mus musculus
 Database cross references - Snx6
ExoCarta ExoCarta_72183
Vesiclepedia VP_72183
Entrez Gene 72183
UniProt Q6P8X1  
 Snx6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx6
Molecular Function
    dynactin binding GO:0034452 IBA
    dynactin binding GO:0034452 ISO
    dynactin binding GO:0034452 ISS
    type I transforming growth factor beta receptor binding GO:0034713 IPI
    phosphatidylinositol binding GO:0035091 IEA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
Biological Process
    intracellular protein transport GO:0006886 ISO
    intracellular protein transport GO:0006886 ISS
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    retrograde transport, endosome to Golgi GO:0042147 IBA
    retrograde transport, endosome to Golgi GO:0042147 ISO
    retrograde transport, endosome to Golgi GO:0042147 ISS
    negative regulation of neuron apoptotic process GO:0043524 IEA
    negative regulation of neuron apoptotic process GO:0043524 ISO
    negative regulation of DNA-templated transcription GO:0045892 IEA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    cellular response to epidermal growth factor stimulus GO:0071364 IEA
    cellular response to epidermal growth factor stimulus GO:0071364 ISO
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IDA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IMP
    cellular response to amyloid-beta GO:1904646 IEA
    cellular response to amyloid-beta GO:1904646 ISO
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 IEA
    lysosome GO:0005764 ISO
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    cytosol GO:0005829 IEA
    retromer complex GO:0030904 ISO
    retromer complex GO:0030904 ISS
    early endosome membrane GO:0031901 ISO
    early endosome membrane GO:0031901 ISS
    tubular endosome GO:0097422 ISO
    tubular endosome GO:0097422 ISS
    postsynaptic early endosome GO:0098842 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Snx6 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Git1  
Two-hybrid Mus musculus
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
2 Snx2 67804
Co-fractionation Mus musculus
3 Snx27 76742
Co-fractionation Mus musculus
4 Shmt1 20425
Co-fractionation Mus musculus
5 Tbc1d5  
Co-fractionation Mus musculus
6 Eed  
Affinity Capture-MS Mus musculus
7 Tmem173  
Proximity Label-MS Mus musculus
8 Ankfy1 11736
Co-fractionation Mus musculus
9 Rab7 19349
Co-fractionation Mus musculus
10 Snx4  
Co-fractionation Mus musculus
11 Vps35 65114
Co-fractionation Mus musculus
12 Snx5 69178
Co-fractionation Mus musculus
13 Tpt1 22070
Co-fractionation Mus musculus
14 Tsnax  
Co-fractionation Mus musculus
15 Rtf1  
Co-fractionation Mus musculus
16 Dctn1 13191
Co-fractionation Mus musculus
17 Vps29 56433
Co-fractionation Mus musculus
18 Snx1  
Co-fractionation Mus musculus
19 Vps26a 30930
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Snx6 is involved
No pathways found





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