Gene description for Snx27
Gene name sorting nexin family member 27
Gene symbol Snx27
Other names/aliases 5730552M22Rik
ESTM45
ESTM47
R75405
Species Mus musculus
 Database cross references - Snx27
ExoCarta ExoCarta_76742
Vesiclepedia VP_76742
Entrez Gene 76742
UniProt Q3UHD6  
 Snx27 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx27
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3-phosphate binding GO:0032266 ISO
    phosphatidylinositol-3-phosphate binding GO:0032266 ISS
    phosphatidylinositol binding GO:0035091 IBA
    ionotropic glutamate receptor binding GO:0035255 ISO
    calcium-dependent protein binding GO:0048306 ISO
Biological Process
    intracellular protein transport GO:0006886 IBA
    intracellular protein transport GO:0006886 ISO
    intracellular protein transport GO:0006886 ISS
    signal transduction GO:0007165 IEA
    endosome to lysosome transport GO:0008333 ISO
    endosomal transport GO:0016197 IMP
    endosomal transport GO:0016197 ISO
    endocytic recycling GO:0032456 IBA
    endocytic recycling GO:0032456 ISO
    endocytic recycling GO:0032456 ISS
    establishment of protein localization to plasma membrane GO:0061951 ISO
    regulation of synapse maturation GO:0090128 IEA
    regulation of synapse maturation GO:0090128 ISO
    neurotransmitter receptor transport to plasma membrane GO:0098877 ISO
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IDA
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IEP
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 IMP
    endosome to plasma membrane protein transport GO:0099638 ISO
    positive regulation of AMPA glutamate receptor clustering GO:1904719 ISO
Subcellular Localization
    immunological synapse GO:0001772 ISO
    immunological synapse GO:0001772 ISS
    endosome GO:0005768 IDA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    retromer complex GO:0030904 ISO
    retromer complex GO:0030904 ISS
    early endosome membrane GO:0031901 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
    WASH complex GO:0071203 ISO
    WASH complex GO:0071203 ISS
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IEP
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IMP
    postsynaptic recycling endosome GO:0098837 IDA
    postsynaptic recycling endosome GO:0098837 IMP
    postsynaptic early endosome GO:0098842 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Snx27 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx27
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snx2 67804
Co-fractionation Mus musculus
2 Ubc  
Reconstituted Complex Mus musculus
3 Snx5 69178
Co-fractionation Mus musculus
4 Tbc1d5  
Co-fractionation Mus musculus
5 Ezr 22350
Co-fractionation Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Snx6 72183
Co-fractionation Mus musculus
8 Slc9a3r1 26941
Co-fractionation Mus musculus
9 Dctn1 13191
Co-fractionation Mus musculus
10 Capzb 12345
Co-fractionation Mus musculus
11 Vps26a 30930
Co-fractionation Mus musculus
12 Abcc4  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Snx27 is involved
No pathways found





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