Gene description for Snx2
Gene name sorting nexin 2
Gene symbol Snx2
Other names/aliases 0610030A03Rik
Species Mus musculus
 Database cross references - Snx2
ExoCarta ExoCarta_67804
Vesiclepedia VP_67804
Entrez Gene 67804
UniProt Q9CWK8  
 Snx2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx2
Molecular Function
    epidermal growth factor receptor binding GO:0005154 IEA
    epidermal growth factor receptor binding GO:0005154 ISO
    insulin receptor binding GO:0005158 IEA
    insulin receptor binding GO:0005158 ISO
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 IEA
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    protein heterodimerization activity GO:0046982 IEA
    protein heterodimerization activity GO:0046982 ISO
    transferrin receptor binding GO:1990459 IEA
    transferrin receptor binding GO:1990459 ISO
    leptin receptor binding GO:1990460 IEA
    leptin receptor binding GO:1990460 ISO
Biological Process
    intracellular protein transport GO:0006886 IEA
    early endosome to Golgi transport GO:0034498 IBA
    retrograde transport, endosome to Golgi GO:0042147 ISO
    retrograde transport, endosome to Golgi GO:0042147 ISS
    lamellipodium morphogenesis GO:0072673 ISO
    lamellipodium morphogenesis GO:0072673 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 IEA
    lysosome GO:0005764 ISO
    endosome GO:0005768 IBA
    endosome GO:0005768 ISO
    cytosol GO:0005829 IEA
    endosome membrane GO:0010008 IBA
    endosome membrane GO:0010008 ISO
    endosome membrane GO:0010008 ISS
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    lamellipodium GO:0030027 IEA
    retromer complex GO:0030904 ISO
    retromer, tubulation complex GO:0030905 IEA
    retromer, tubulation complex GO:0030905 ISO
    early endosome membrane GO:0031901 IEA
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Snx2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ankfy1 11736
Co-fractionation Mus musculus
2 Snx6 72183
Co-fractionation Mus musculus
3 Dctn1 13191
Co-fractionation Mus musculus
4 Vps26a 30930
Co-fractionation Mus musculus
5 Atp6v1c1  
Co-fractionation Mus musculus
6 Tmem173  
Proximity Label-MS Mus musculus
7 Snx5 69178
Co-fractionation Mus musculus
8 Atxn1  
Affinity Capture-MS Mus musculus
9 Kctd13  
Affinity Capture-MS Mus musculus
10 Rab7 19349
Co-fractionation Mus musculus
11 Vps29 56433
Co-fractionation Mus musculus
12 Snx1  
Co-fractionation Mus musculus
13 Snx3 54198
Co-fractionation Mus musculus
14 Shmt1 20425
Co-fractionation Mus musculus
15 Tbcd  
Co-fractionation Mus musculus
16 Vps26b  
Co-fractionation Mus musculus
17 Fnbp1  
Co-fractionation Mus musculus
18 Snx4  
Co-fractionation Mus musculus
19 Vps35 65114
Co-fractionation Mus musculus
20 Tbc1d5  
Co-fractionation Mus musculus
21 Eed  
Affinity Capture-MS Mus musculus
22 Fancd2  
Affinity Capture-MS Mus musculus
23 Snx27 76742
Co-fractionation Mus musculus
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