Gene description for Snx3
Gene name sorting nexin 3
Gene symbol Snx3
Other names/aliases SDP3
Species Mus musculus
 Database cross references - Snx3
ExoCarta ExoCarta_54198
Vesiclepedia VP_54198
Entrez Gene 54198
 Snx3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx3
Molecular Function
    phosphatidylinositol-3-phosphate binding GO:0032266 ISO
    protein phosphatase binding GO:0019903 ISO
    phosphatidylinositol binding GO:0035091 IEA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
    lipid binding GO:0008289 IEA
    phosphatidylinositol-5-phosphate binding GO:0010314 IDA
    protein binding GO:0005515 IPI
Biological Process
    intralumenal vesicle formation GO:0070676 ISO
    transport GO:0006810 IEA
    protein to membrane docking GO:0022615 ISO
    heme biosynthetic process GO:0006783 ISO
    protein transport GO:0015031 IEA
    negative regulation of early endosome to late endosome transport GO:2000642 ISO
    response to bacterium GO:0009617 ISO
    regulation of intracellular protein transport GO:0033157 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    negative regulation of viral entry into host cell GO:0046597 ISO
    regulation of Wnt signaling pathway GO:0030111 ISO
    negative regulation of protein catabolic process GO:0042177 ISO
    vesicle organization GO:0016050 IBA
    negative regulation of protein transport GO:0051224 ISO
    endocytosis GO:0006897 IBA
    negative regulation of phagocytosis GO:0050765 ISO
    regulation of cellular protein metabolic process GO:0032268 IMP
    hemoglobin biosynthetic process GO:0042541 IMP
    membrane invagination GO:0010324 ISO
    transferrin transport GO:0033572 IMP
Subcellular Localization
    endosome membrane GO:0010008 ISO
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
    early phagosome GO:0032009 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    early endosome GO:0005769 ISO
    clathrin-coated vesicle GO:0030136 ISO
    cytoplasm GO:0005737 ISO
    extrinsic component of membrane GO:0019898 IBA
    cytoplasmic vesicle GO:0031410 IEA
    early endosome membrane GO:0031901 ISO
    retromer complex GO:0030904 ISO
    endosome GO:0005768 IBA
 Experiment description of studies that identified Snx3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Snx3 is involved
No pathways found





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