Gene description for Shmt1
Gene name	serine hydroxymethyltransferase 1 (soluble)
Gene symbol	Shmt1
Other names/aliases	AI324848 AI385541 C81125 Shmt mshmt mshmt1 mshmt2
Species	Mus musculus
Database cross references - Shmt1
ExoCarta	ExoCarta_20425
Vesiclepedia	VP_20425
Entrez Gene	20425
UniProt	P50431
Shmt1 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Shmt1

Molecular Function     mRNA regulatory element binding translation repressor activity GO:0000900 IEA     mRNA regulatory element binding translation repressor activity GO:0000900 ISO     glycine hydroxymethyltransferase activity GO:0004372 IBA     glycine hydroxymethyltransferase activity GO:0004372 IGI     glycine hydroxymethyltransferase activity GO:0004372 IMP     glycine hydroxymethyltransferase activity GO:0004372 ISO     glycine hydroxymethyltransferase activity GO:0004372 ISS     L-allo-threonine aldolase activity GO:0008732 ISO     amino acid binding GO:0016597 ISO     pyridoxal phosphate binding GO:0030170 IBA     pyridoxal phosphate binding GO:0030170 ISO     pyridoxal phosphate binding GO:0030170 ISS     small molecule binding GO:0036094 ISO     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     mRNA 5'-UTR binding GO:0048027 IEA     mRNA 5'-UTR binding GO:0048027 ISO     serine binding GO:0070905 IEA     serine binding GO:0070905 ISO Biological Process     dTMP biosynthetic process GO:0006231 IMP     glycine metabolic process GO:0006544 ISO     glycine metabolic process GO:0006544 ISS     glycine biosynthetic process GO:0006545 ISO     L-serine metabolic process GO:0006563 ISO     L-serine metabolic process GO:0006563 ISS     L-serine catabolic process GO:0006565 IEA     L-serine catabolic process GO:0006565 ISO     one-carbon metabolic process GO:0006730 IC     purine nucleobase biosynthetic process GO:0009113 IEA     purine nucleobase biosynthetic process GO:0009113 ISO     negative regulation of translation GO:0017148 IEA     negative regulation of translation GO:0017148 ISO     glycine biosynthetic process from serine GO:0019264 IBA     glycine biosynthetic process from serine GO:0019264 IEA     glycine biosynthetic process from serine GO:0019264 ISO     tetrahydrofolate interconversion GO:0035999 IEA     tetrahydrofolate interconversion GO:0035999 IMP     tetrahydrofolate interconversion GO:0035999 ISO     tetrahydrofolate metabolic process GO:0046653 IBA     tetrahydrofolate metabolic process GO:0046653 ISO     tetrahydrofolate metabolic process GO:0046653 ISS     folic acid metabolic process GO:0046655 IEA     folic acid metabolic process GO:0046655 ISO     protein homotetramerization GO:0051289 ISO     protein homotetramerization GO:0051289 ISS     cellular response to tetrahydrofolate GO:1904482 IEA     cellular response to tetrahydrofolate GO:1904482 ISO     cellular response to leukemia inhibitory factor GO:1990830 IEP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IGI     nucleus GO:0005634 IMP     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IBA     mitochondrion GO:0005739 HDA     mitochondrion GO:0005739 IBA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS