Gene description for Snx5
Gene name sorting nexin 5
Gene symbol Snx5
Other names/aliases 0910001N05Rik
1810032P22Rik
AU019504
D2Ertd52e
Species Mus musculus
 Database cross references - Snx5
ExoCarta ExoCarta_69178
Vesiclepedia VP_69178
Entrez Gene 69178
UniProt Q9D8U8  
 Snx5 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx5
Molecular Function
    dynactin binding GO:0034452 ISO
    lipid binding GO:0008289 IEA
    phosphatidylinositol binding GO:0035091 ISO
Biological Process
    pinocytosis GO:0006907 ISO
    endocytosis GO:0006897 IBA
    retrograde transport, endosome to Golgi GO:0042147 ISO
    vesicle organization GO:0016050 IBA
    intracellular protein transport GO:0006886 IEA
    protein transport GO:0015031 IEA
    transport GO:0006810 IEA
Subcellular Localization
    early endosome membrane GO:0031901 ISO
    extrinsic component of membrane GO:0019898 IBA
    retromer complex GO:0030904 ISO
    extrinsic component of endosome membrane GO:0031313 ISO
    plasma membrane GO:0005886 IEA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISO
    cell projection GO:0042995 IEA
    cytoplasmic vesicle GO:0031410 IEA
    endosome GO:0005768 IBA
    macropinocytic cup GO:0070685 ISO
    membrane GO:0016020 IEA
    tubular endosome GO:0097422 ISO
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Snx5 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Snx5 is involved
PathwayEvidenceSource
Golgi Associated Vesicle Biogenesis IEA Reactome





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