Gene description for Lamtor5
Gene name late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Gene symbol Lamtor5
Other names/aliases 1110003H18Rik
Hbxip
XIP
Species Mus musculus
 Database cross references - Lamtor5
ExoCarta ExoCarta_68576
Entrez Gene 68576
UniProt Q9D1L9  
 Lamtor5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lamtor5
Molecular Function
    protein complex scaffold GO:0032947 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
Biological Process
    cellular response to amino acid stimulus GO:0071230 ISO
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    protein localization to lysosome GO:0061462 ISO
    positive regulation of TOR signaling GO:0032008 ISO
    viral genome replication GO:0019079 IEA
    regulation of cell size GO:0008361 ISO
Subcellular Localization
    lysosome GO:0005764 ISO
    cytoplasm GO:0005737 IEA
    cytosol GO:0005829 ISO
    Ragulator complex GO:0071986 ISO
 Experiment description of studies that identified Lamtor5 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lamtor5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lamtor5 is involved
No pathways found





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