Gene description for Lamtor5
Gene name late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Gene symbol Lamtor5
Other names/aliases 1110003H18Rik
Hbxip
XIP
Species Mus musculus
 Database cross references - Lamtor5
ExoCarta ExoCarta_68576
Vesiclepedia VP_68576
Entrez Gene 68576
UniProt Q9D1L9  
 Lamtor5 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lamtor5
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    molecular adaptor activity GO:0060090 ISO
    molecular adaptor activity GO:0060090 ISS
Biological Process
    regulation of cell size GO:0008361 ISO
    regulation of cell size GO:0008361 ISS
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of TOR signaling GO:0032008 ISO
    positive regulation of TOR signaling GO:0032008 ISS
    positive regulation of interleukin-8 production GO:0032757 ISO
    TORC1 signaling GO:0038202 NAS
    negative regulation of apoptotic process GO:0043066 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    protein localization to lysosome GO:0061462 ISO
    protein localization to lysosome GO:0061462 ISS
    cellular response to amino acid stimulus GO:0071230 IBA
    cellular response to amino acid stimulus GO:0071230 ISO
    cellular response to amino acid stimulus GO:0071230 ISS
    positive regulation of protein localization to nucleus GO:1900182 ISO
    positive regulation of TORC1 signaling GO:1904263 IBA
    positive regulation of TORC1 signaling GO:1904263 ISO
    positive regulation of TORC1 signaling GO:1904263 ISS
    positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1905636 ISO
    negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO
Subcellular Localization
    lysosome GO:0005764 IBA
    lysosome GO:0005764 ISO
    lysosome GO:0005764 ISS
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    lysosomal membrane GO:0005765 NAS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    late endosome membrane GO:0031902 NAS
    protein-containing complex GO:0032991 ISO
    Ragulator complex GO:0071986 IBA
    Ragulator complex GO:0071986 ISO
    Ragulator complex GO:0071986 ISS
    FNIP-folliculin RagC/D GAP GO:1990877 ISO
 Experiment description of studies that identified Lamtor5 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lamtor5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tfe3  
Affinity Capture-MS Mus musculus
2 Snx5 69178
Co-fractionation Mus musculus
View the network image/svg+xml



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