Gene description for Slc9a3r1
Gene name solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
Gene symbol Slc9a3r1
Other names/aliases EBP-50
NHE-RF
NHERF-1
NHERF1
Species Mus musculus
 Database cross references - Slc9a3r1
ExoCarta ExoCarta_26941
Vesiclepedia VP_26941
Entrez Gene 26941
UniProt P70441  
 Slc9a3r1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc9a3r1
Molecular Function
    beta-2 adrenergic receptor binding GO:0031698 ISO
    beta-catenin binding GO:0008013 ISO
    protein self-association GO:0043621 ISO
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 ISO
    protein complex binding GO:0032403 ISO
    receptor binding GO:0005102 ISO
    phosphatase binding GO:0019902 ISO
    growth factor receptor binding GO:0070851 ISO
    dopamine receptor binding GO:0050780 IDA
    chloride channel regulator activity GO:0017081 ISO
    protein domain specific binding GO:0019904 ISO
    protein complex scaffold GO:0032947 ISO
Biological Process
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IMP
    negative regulation of cell motility GO:2000146 IMP
    Wnt signaling pathway GO:0016055 IEA
    actin cytoskeleton organization GO:0030036 IMP
    glutathione transport GO:0034635 IMP
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO
    auditory receptor cell stereocilium organization GO:0060088 IMP
    negative regulation of sodium:proton antiporter activity GO:0032416 IMP
    regulation of protein kinase activity GO:0045859 IMP
    renal sodium ion transport GO:0003096 IMP
    cellular protein localization GO:0034613 IMP
    renal phosphate ion absorption GO:0097291 ISO
    cAMP-mediated signaling GO:0019933 ISA
    bile acid secretion GO:0032782 IMP
    negative regulation of phosphatidylinositol 3-kinase signaling GO:0014067 IMP
    negative regulation of protein kinase B signaling GO:0051898 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    cellular phosphate ion homeostasis GO:0030643 IMP
    sensory perception of sound GO:0007605 IMP
    negative regulation of cell migration GO:0030336 IGI
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IMP
    regulation of excretion GO:0044062 IMP
    negative regulation of sodium ion transport GO:0010766 IMP
    microvillus assembly GO:0030033 ISO
    renal absorption GO:0070293 IMP
    adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IMP
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISO
Subcellular Localization
    apical part of cell GO:0045177 IDA
    vesicle GO:0031982 ISO
    extracellular exosome GO:0070062 ISO
    microvillus GO:0005902 ISO
    cytoplasm GO:0005737 ISO
    brush border membrane GO:0031526 IDA
    plasma membrane GO:0005886 ISO
    cell periphery GO:0071944 ISO
    apical plasma membrane GO:0016324 ISO
    intracellular GO:0005622 IMP
    stereocilium bundle tip GO:0032426 IDA
    microvillus membrane GO:0031528 ISO
    membrane GO:0016020 ISO
    stereocilium GO:0032420 IDA
    sperm midpiece GO:0097225 IDA
    centrosome GO:0005813 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    cell projection GO:0042995 IEA
    membrane raft GO:0045121 ISO
    cell GO:0005623 IMP
 Experiment description of studies that identified Slc9a3r1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc9a3r1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC9A3 6550
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Slc9a3r1 is involved
No pathways found





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