Gene description for SLC9A3
Gene name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Gene symbol SLC9A3
Other names/aliases NHE3
Species Homo sapiens
 Database cross references - SLC9A3
ExoCarta ExoCarta_6550
Entrez Gene 6550
HGNC 11073
MIM 182307
UniProt P48764  
 SLC9A3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC9A3
Molecular Function
    protein binding GO:0005515 IPI
    PDZ domain binding GO:0030165 ISS
    sodium:proton antiporter activity GO:0015385 ISS
Biological Process
    transmembrane transport GO:0055085 TAS
    ion transport GO:0006811 TAS
    regulation of pH GO:0006885 IEA
    hydrogen ion transmembrane transport GO:1902600 IEA
    sodium ion transmembrane transport GO:0035725 ISS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 ISS
    apical plasma membrane GO:0016324 ISS
    brush border membrane GO:0031526 ISS
    integral component of membrane GO:0016021 IEA
    brush border GO:0005903 ISS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLC9A3 in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC9A3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHP2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 PDZK1 5174
Two-hybrid Homo sapiens
3 SLC9A3R2 9351
Reconstituted Complex Homo sapiens
4 Slc9a3r1  
Two-hybrid Mus musculus
5 LRP2 4036
Invivo Homo sapiens
Invitro Homo sapiens
6 SLC9A3R1 9368
Affinity Capture-Western Homo sapiens
7 CHP1 11261
Reconstituted Complex Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SLC9A3 is involved
Sodium/Proton exchangers TAS Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here