Gene description for Gna11
Gene name guanine nucleotide binding protein, alpha 11
Gene symbol Gna11
Other names/aliases Dsk7
E430025L19
Species Mus musculus
 Database cross references - Gna11
ExoCarta ExoCarta_14672
Vesiclepedia VP_14672
Entrez Gene 14672
UniProt P21278  
 Gna11 identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
 Gene ontology annotations for Gna11
Molecular Function
    G protein-coupled receptor binding GO:0001664 IBA
    G protein-coupled receptor binding GO:0001664 IEA
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 ISA
    GTPase activity GO:0003924 TAS
    G protein activity GO:0003925 IMP
    G protein activity GO:0003925 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
    enzyme regulator activity GO:0030234 IMP
    enzyme regulator activity GO:0030234 ISO
    G-protein beta/gamma-subunit complex binding GO:0031683 IBA
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
    alkylglycerophosphoethanolamine phosphodiesterase activity GO:0047391 ISO
Biological Process
    skeletal system development GO:0001501 IMP
    action potential GO:0001508 IBA
    action potential GO:0001508 IDA
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    G protein-coupled receptor signaling pathway GO:0007186 ISA
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 IBA
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IGI
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IMP
    phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway GO:0007207 IGI
    glutamate receptor signaling pathway GO:0007215 IMP
    heart development GO:0007507 IMP
    regulation of blood pressure GO:0008217 IGI
    positive regulation of insulin secretion GO:0032024 IGI
    positive regulation of insulin secretion GO:0032024 IMP
    regulation of melanocyte differentiation GO:0045634 IMP
    developmental pigmentation GO:0048066 IMP
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IBA
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IGI
    cellular response to pH GO:0071467 IMP
    endothelin receptor signaling pathway GO:0086100 IGI
    ion channel modulating, G protein-coupled receptor signaling pathway GO:0099105 IGI
    cranial skeletal system development GO:1904888 IGI
    ligand-gated ion channel signaling pathway GO:1990806 IGI
    ligand-gated ion channel signaling pathway GO:1990806 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    heterotrimeric G-protein complex GO:0005834 IBA
    heterotrimeric G-protein complex GO:0005834 ISA
    heterotrimeric G-protein complex GO:0005834 ISO
    heterotrimeric G-protein complex GO:0005834 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IGI
    synapse GO:0045202 IEA
 Experiment description of studies that identified Gna11 in exosomes
1
Experiment ID 73
MISEV standards
EM
Biophysical techniques
HSP70|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors "Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ"
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
 Protein-protein interactions for Gna11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Wfs1  
Co-fractionation Mus musculus
2 Ptgir 19222
Affinity Capture-Western Mus musculus
3 Mapt  
Affinity Capture-MS Mus musculus
4 Agap2  
Affinity Capture-MS Mus musculus
5 Slc9a3r1 26941
Co-fractionation Mus musculus
6 Tjp1  
Co-fractionation Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Gna11 is involved
PathwayEvidenceSource
Acetylcholine regulates insulin secretion IEA Reactome
ADP signalling through P2Y purinoceptor 1 IEA Reactome
Cellular responses to mechanical stimuli IEA Reactome
Cellular responses to stimuli IEA Reactome
Chaperonin-mediated protein folding IEA Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding IEA Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion IEA Reactome
Free fatty acids regulate insulin secretion IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (q) signalling events IEA Reactome
G-protein activation IEA Reactome
G-protein mediated events IEA Reactome
GPCR downstream signalling IEA Reactome
Hemostasis IEA Reactome
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells IEA Reactome
Integration of energy metabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Opioid Signalling IEA Reactome
Platelet activation, signaling and aggregation IEA Reactome
PLC beta mediated events IEA Reactome
Protein folding IEA Reactome
Regulation of insulin secretion IEA Reactome
Response of endothelial cells to shear stress IEA Reactome
Signal amplification IEA Reactome
Signal Transduction IEA Reactome
Signaling by GPCR IEA Reactome
Thrombin signalling through proteinase activated receptors (PARs) IEA Reactome
Thromboxane signalling through TP receptor IEA Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells IEA Reactome





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