Gene description for Gna11
Gene name guanine nucleotide binding protein, alpha 11
Gene symbol Gna11
Other names/aliases Dsk7
E430025L19
Species Mus musculus
 Database cross references - Gna11
ExoCarta ExoCarta_14672
Entrez Gene 14672
UniProt P21278  
 Gna11 identified in exosomes derived from the following tissue/cell type
Embryonic fibroblasts 18494037    
 Gene ontology annotations for Gna11
Molecular Function
    type 2A serotonin receptor binding GO:0031826 ISO
    signal transducer activity GO:0004871 IBA
    metal ion binding GO:0046872 IEA
    G-protein beta/gamma-subunit complex binding GO:0031683 IBA
    nucleotide binding GO:0000166 IEA
    protein complex binding GO:0032403 ISO
    G-protein coupled receptor binding GO:0001664 IEA
    GTP binding GO:0005525 ISO
    guanyl nucleotide binding GO:0019001 IEA
    GTPase activity GO:0003924 TAS
Biological Process
    action potential GO:0001508 IDA
    cellular response to pH GO:0071467 IMP
    signal transduction GO:0007165 IEA
    regulation of melanocyte differentiation GO:0045634 IMP
    phospholipase C-activating dopamine receptor signaling pathway GO:0060158 IGI
    developmental pigmentation GO:0048066 IMP
    glutamate receptor signaling pathway GO:0007215 IMP
    heart development GO:0007507 IMP
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 IBA
    skeletal system development GO:0001501 IMP
    G-protein coupled receptor signaling pathway GO:0007186 ISO
Subcellular Localization
    heterotrimeric G-protein complex GO:0005834 TAS
    protein complex GO:0043234 ISO
    plasma membrane GO:0005886 ISO
    lysosomal membrane GO:0005765 ISO
    cytoplasm GO:0005737 IEA
    membrane GO:0016020 ISO
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Gna11 in exosomes
1
Experiment ID 73
ISEV standards
EM
EV Biophysical techniques
HSP70|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 18494037    
Organism Mus musculus
Experiment description Difference gel electrophoresis analysis of Ras-transformed fibroblast cell-derived exosomes.
Authors Ji H, Erfani N, Tauro BJ, Kapp EA, Zhu HJ, Moritz RL, Lim JW, Simpson RJ
Journal name ELEC
Publication year 2008
Sample Embryonic fibroblasts
Sample name NIH3T3
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA]
Western blotting
 Protein-protein interactions for Gna11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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