Gene description for Ythdf2
Gene name YTH domain family 2
Gene symbol Ythdf2
Other names/aliases 9430020E02Rik
HGRG8
NY-REN-2
Species Mus musculus
 Database cross references - Ythdf2
ExoCarta ExoCarta_213541
Vesiclepedia VP_213541
Entrez Gene 213541
UniProt Q91YT7  
 Ythdf2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ythdf2
Molecular Function
    RNA binding GO:0003723 IEA
    mRNA binding GO:0003729 IBA
    C5-methylcytidine-containing RNA reader activity GO:0062153 ISO
    C5-methylcytidine-containing RNA reader activity GO:0062153 ISS
    N6-methyladenosine-containing RNA reader activity GO:1990247 IBA
    N6-methyladenosine-containing RNA reader activity GO:1990247 IMP
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISS
Biological Process
    oocyte maturation GO:0001556 IMP
    mRNA catabolic process GO:0006402 IMP
    mRNA catabolic process GO:0006402 ISO
    gamete generation GO:0007276 IMP
    spermatogonial cell division GO:0007284 IMP
    regulation of cell adhesion GO:0030155 IMP
    stress granule assembly GO:0034063 ISO
    stress granule assembly GO:0034063 ISS
    regulation of mRNA stability GO:0043488 IMP
    regulation of mRNA stability GO:0043488 ISO
    innate immune response GO:0045087 IEA
    negative regulation of Notch signaling pathway GO:0045746 ISS
    positive regulation of translational initiation GO:0045948 IMP
    positive regulation of translational initiation GO:0045948 ISS
    embryonic morphogenesis GO:0048598 ISS
    regulation of neurogenesis GO:0050767 IMP
    regulation of neurogenesis GO:0050767 ISO
    regulation of neurogenesis GO:0050767 ISS
    negative regulation of type I interferon-mediated signaling pathway GO:0060339 ISO
    negative regulation of type I interferon-mediated signaling pathway GO:0060339 ISS
    mRNA destabilization GO:0061157 IBA
    mRNA destabilization GO:0061157 IMP
    mRNA destabilization GO:0061157 ISO
    organelle assembly GO:0070925 ISO
    organelle assembly GO:0070925 ISS
    hematopoietic stem cell proliferation GO:0071425 IMP
    endothelial to hematopoietic transition GO:0098508 ISS
    regulation of hematopoietic stem cell differentiation GO:1902036 IMP
    regulation of meiotic cell cycle process involved in oocyte maturation GO:1903538 IMP
    positive regulation of cap-independent translational initiation GO:1903679 ISO
    positive regulation of cap-independent translational initiation GO:1903679 ISS
    regulation of rRNA processing GO:2000232 ISO
    regulation of rRNA processing GO:2000232 ISS
    negative regulation of stem cell differentiation GO:2000737 ISO
    negative regulation of stem cell differentiation GO:2000737 ISS
Subcellular Localization
    P-body GO:0000932 ISO
    P-body GO:0000932 ISS
    nucleus GO:0005634 IMP
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    cytoplasmic stress granule GO:0010494 ISO
    cytoplasmic stress granule GO:0010494 ISS
    centriolar satellite GO:0034451 IEA
    centriolar satellite GO:0034451 ISO
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
 Experiment description of studies that identified Ythdf2 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ythdf2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RBM7  
Two-hybrid Homo sapiens
2 Zbtb7b  
Affinity Capture-MS Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Fzr1  
Affinity Capture-MS Mus musculus
5 Foxp3  
Affinity Capture-MS Mus musculus
6 Dusp14  
Two-hybrid Mus musculus
7 RHOA 387
Two-hybrid Homo sapiens
8 Gnb2l1 14694
Two-hybrid Mus musculus
9 Twist1  
Proximity Label-MS Mus musculus
10 DMRTB1  
Two-hybrid Homo sapiens
11 Pef1  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Ythdf2 is involved
No pathways found





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