Gene description for Arpc2
Gene name actin related protein 2/3 complex, subunit 2
Gene symbol Arpc2
Other names/aliases 2210023N03Rik
34kDa
p34-Arc
Species Mus musculus
 Database cross references - Arpc2
ExoCarta ExoCarta_76709
Vesiclepedia VP_76709
Entrez Gene 76709
UniProt Q9CVB6  
 Arpc2 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Arpc2
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of cytoskeleton GO:0005200 ISO
    actin filament binding GO:0051015 ISO
    actin binding GO:0003779 IEA
Biological Process
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
    positive regulation of lamellipodium assembly GO:0010592 ISO
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP
    regulation of actin filament polymerization GO:0030833 IEA
    positive regulation of actin filament polymerization GO:0030838 IDA
Subcellular Localization
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 IDA
    actin cytoskeleton GO:0015629 IEA
    cytoplasm GO:0005737 ISO
    cell junction GO:0030054 IEA
    cell projection GO:0042995 IEA
    focal adhesion GO:0005925 ISO
    cell leading edge GO:0031252 IDA
    endosome GO:0005768 IDA
    Arp2/3 protein complex GO:0005885 TAS
    neuron projection GO:0043005 IEA
    cytoskeleton GO:0005856 IEA
    synapse GO:0045202 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Arpc2 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Arpc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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