Gene description for Ssh1
Gene name slingshot homolog 1 (Drosophila)
Gene symbol Ssh1
Other names/aliases AW551225
Gm1394
Gm1395
SSH-1
mSSH-1L
Species Mus musculus
 Database cross references - Ssh1
ExoCarta ExoCarta_231637
Entrez Gene 231637
UniProt Q76I79  
 Ssh1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ssh1
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IEA
    phosphatase activity GO:0016791 IEA
    actin binding GO:0003779 ISO
    protein tyrosine/serine/threonine phosphatase activity GO:0008138 IBA
    phosphoprotein phosphatase activity GO:0004721 ISO
    DNA binding GO:0003677 IEA
    hydrolase activity GO:0016787 IEA
Biological Process
    cell morphogenesis GO:0000902 ISO
    protein dephosphorylation GO:0006470 ISO
    regulation of cellular protein metabolic process GO:0032268 ISO
    cellular response to ATP GO:0071318 ISO
    regulation of axonogenesis GO:0050770 IBA
    dephosphorylation GO:0016311 IEA
    actin cytoskeleton organization GO:0030036 ISO
    regulation of actin polymerization or depolymerization GO:0008064 IBA
    regulation of lamellipodium assembly GO:0010591 IBA
Subcellular Localization
    plasma membrane GO:0005886 ISO
    cytoskeleton GO:0005856 IEA
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Ssh1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ssh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ssh1 is involved
No pathways found





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