Gene description for Arpc3
Gene name actin related protein 2/3 complex, subunit 3
Gene symbol Arpc3
Other names/aliases 1110006A04Rik
21kDa
AA408672
AI788639
p21-Ar
p21Arc
Species Mus musculus
 Database cross references - Arpc3
ExoCarta ExoCarta_56378
Entrez Gene 56378
UniProt Q9JM76  
 Arpc3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Mov neuroglial cells 15210972    
 Gene ontology annotations for Arpc3
Molecular Function
    actin binding GO:0003779 IEA
    actin filament binding GO:0051015 ISO
    structural constituent of cytoskeleton GO:0005200 ISO
Biological Process
    regulation of actin filament polymerization GO:0030833 IEA
    Arp2/3 complex-mediated actin nucleation GO:0034314 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    Arp2/3 protein complex GO:0005885 TAS
    cytoplasm GO:0005737 IEA
    focal adhesion GO:0005925 ISO
    cell projection GO:0042995 IEA
    lamellipodium GO:0030027 IDA
    cytoskeleton GO:0005856 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Arpc3 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 39
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|HSC70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Arpc3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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