Gene description for Elavl1
Gene name ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
Gene symbol Elavl1
Other names/aliases 2410055N02Rik
HUR
Hua
W91709
Species Mus musculus
 Database cross references - Elavl1
ExoCarta ExoCarta_15568
Vesiclepedia VP_15568
Entrez Gene 15568
UniProt P70372  
 Elavl1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Elavl1
Molecular Function
    RNA binding GO:0003723 ISO
    RNA binding GO:0003723 ISS
    double-stranded RNA binding GO:0003725 ISO
    mRNA binding GO:0003729 IDA
    mRNA binding GO:0003729 ISO
    mRNA 3'-UTR binding GO:0003730 IDA
    mRNA 3'-UTR binding GO:0003730 ISO
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    miRNA binding GO:0035198 ISO
    miRNA binding GO:0035198 ISS
    mRNA 3'-UTR AU-rich region binding GO:0035925 IDA
    mRNA 3'-UTR AU-rich region binding GO:0035925 ISO
    mRNA 3'-UTR AU-rich region binding GO:0035925 ISS
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    lncRNA binding GO:0106222 IDA
    lncRNA binding GO:0106222 IPI
Biological Process
    lncRNA-mediated post-transcriptional gene silencing GO:0000512 IMP
    regulation of translation GO:0006417 ISO
    protein import into nucleus GO:0006606 IMP
    post-transcriptional gene silencing GO:0016441 IDA
    positive regulation of superoxide anion generation GO:0032930 IEA
    positive regulation of superoxide anion generation GO:0032930 ISO
    positive regulation of translation GO:0045727 IDA
    positive regulation of translation GO:0045727 IMP
    positive regulation of translation GO:0045727 ISO
    mRNA stabilization GO:0048255 IDA
    mRNA stabilization GO:0048255 IMP
    mRNA stabilization GO:0048255 IMP
    mRNA stabilization GO:0048255 ISO
    mRNA stabilization GO:0048255 ISO
    mRNA stabilization GO:0048255 ISS
    protein homooligomerization GO:0051260 ISO
    protein homooligomerization GO:0051260 ISS
    negative regulation of miRNA-mediated gene silencing GO:0060965 ISO
    negative regulation of miRNA-mediated gene silencing GO:0060965 ISS
    mRNA destabilization GO:0061157 IEA
    mRNA destabilization GO:0061157 ISO
    3'-UTR-mediated mRNA stabilization GO:0070935 IDA
    3'-UTR-mediated mRNA stabilization GO:0070935 ISO
    3'-UTR-mediated mRNA stabilization GO:0070935 ISS
    regulation of stem cell population maintenance GO:2000036 IMP
Subcellular Localization
    P-body GO:0000932 IEA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    cytoplasmic stress granule GO:0010494 IDA
    sarcoplasm GO:0016528 IDA
    cytoplasmic vesicle GO:0031410 IPI
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IEP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IEP
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified Elavl1 in exosomes
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Elavl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mdm2  
Affinity Capture-Western Mus musculus
2 Fxr1 14359
Affinity Capture-MS Mus musculus
3 Lcn2  
Co-fractionation Mus musculus
4 CEP128  
Affinity Capture-MS Homo sapiens
5 Upf1 19704
Co-fractionation Mus musculus
6 Mycbp2 105689
Affinity Capture-MS Mus musculus
7 Pou5f1  
Affinity Capture-MS Mus musculus
8 ELAVL2 1993
Affinity Capture-MS Homo sapiens
9 Pde4dip  
Affinity Capture-MS Mus musculus
10 Fmr1  
Affinity Capture-MS Mus musculus
11 Kctd13  
Affinity Capture-MS Mus musculus
12 MRPL27 51264
Affinity Capture-MS Homo sapiens
13 PRRC2B  
Two-hybrid Homo sapiens
14 LRRC16A 55604
Affinity Capture-MS Homo sapiens
15 Fzr1  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
16 MKRN1 23608
Affinity Capture-MS Homo sapiens
17 SPG11 80208
Affinity Capture-MS Homo sapiens
18 SNRNP70 6625
Affinity Capture-MS Homo sapiens
19 UPF1 5976
Affinity Capture-MS Homo sapiens
20 USP24 23358
Affinity Capture-MS Homo sapiens
21 Tnpo1 238799
Co-fractionation Mus musculus
22 Rbm38  
Two-hybrid Mus musculus
23 Sqstm1  
Affinity Capture-MS Mus musculus
24 Eed  
Affinity Capture-MS Mus musculus
25 Atxn1  
Proximity Label-MS Mus musculus
26 Fancd2  
Affinity Capture-MS Mus musculus
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