Gene description for Parp1
Gene name poly (ADP-ribose) polymerase family, member 1
Gene symbol Parp1
Other names/aliases 5830444G22Rik
AI893648
ARTD1
Adprp
Adprt1
C80510
PARP
PPOL
parp-1
sPARP-1
Species Mus musculus
 Database cross references - Parp1
ExoCarta ExoCarta_11545
Vesiclepedia VP_11545
Entrez Gene 11545
 Parp1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Parp1
Molecular Function
    transferase activity GO:0016740 IEA
    chromatin binding GO:0003682 IDA
    poly(A) RNA binding GO:0044822 ISO
    R-SMAD binding GO:0070412 ISO
    protein kinase binding GO:0019901 ISO
    protein binding GO:0005515 IPI
    protein N-terminus binding GO:0047485 ISO
    transcription factor binding GO:0008134 ISO
    zinc ion binding GO:0008270 IEA
    enzyme binding GO:0019899 ISO
    transferase activity, transferring glycosyl groups GO:0016757 IEA
    identical protein binding GO:0042802 ISO
    NAD binding GO:0051287 ISO
    DNA binding GO:0003677 IEA
    metal ion binding GO:0046872 IEA
    NAD+ ADP-ribosyltransferase activity GO:0003950 ISO
Biological Process
    DNA damage response, detection of DNA damage GO:0042769 ISO
    mitochondrial DNA repair GO:0043504 ISO
    mitochondrion organization GO:0007005 ISO
    base-excision repair GO:0006284 IMP
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription regulatory region DNA binding GO:2000679 ISO
    protein autoprocessing GO:0016540 ISO
    cellular response to superoxide GO:0071451 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    behavioral response to cocaine GO:0048148 IMP
    signal transduction involved in regulation of gene expression GO:0023019 ISO
    positive regulation of SMAD protein import into nucleus GO:0060391 ISO
    double-strand break repair GO:0006302 ISO
    DNA repair GO:0006281 TAS
    cellular response to DNA damage stimulus GO:0006974 IEA
    protein modification process GO:0036211 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    DNA metabolic process GO:0006259 IMP
    regulation of single strand break repair GO:1903516 IMP
    protein ADP-ribosylation GO:0006471 ISO
    regulation of growth rate GO:0040009 IMP
    cellular response to oxidative stress GO:0034599 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    protein poly-ADP-ribosylation GO:0070212 ISO
    cellular response to insulin stimulus GO:0032869 ISO
    telomere maintenance GO:0000723 IMP
    mitochondrial DNA metabolic process GO:0032042 ISO
Subcellular Localization
    nuclear envelope GO:0005635 ISO
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    transcription factor complex GO:0005667 ISO
    nucleolus GO:0005730 ISO
    membrane GO:0016020 ISO
    mitochondrion GO:0005739 ISO
    protein complex GO:0043234 ISO
    nucleus GO:0005634 TAS
 Experiment description of studies that identified Parp1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Parp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Parp1 is involved
No pathways found





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