Gene description for Hist1h1e
Gene name histone cluster 1, H1e
Gene symbol Hist1h1e
Other names/aliases H1-4
H1.4
H1e
H1f4
H1s-4
H1var2
Species Mus musculus
 Database cross references - Hist1h1e
ExoCarta ExoCarta_50709
Entrez Gene 50709
UniProt P43274  
 Hist1h1e identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Neural stem cells 25242146    
 Gene ontology annotations for Hist1h1e
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IDA
Biological Process
    nucleosome positioning GO:0016584 IMP
    nucleosome assembly GO:0006334 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IGI
Subcellular Localization
    nucleosome GO:0000786 IEA
    chromosome GO:0005694 IEA
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified Hist1h1e in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hist1h1e
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hist1h1e is involved
No pathways found





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