Gene description for Mtap
Gene name methylthioadenosine phosphorylase
Gene symbol Mtap
Other names/aliases 1300019I21Rik
MSAP
Species Mus musculus
 Database cross references - Mtap
ExoCarta ExoCarta_66902
Entrez Gene 66902
UniProt Q9CQ65  
 Mtap identified in exosomes derived from the following tissue/cell type
Brain cancer cells 19109410    
 Gene ontology annotations for Mtap
Molecular Function
    catalytic activity GO:0003824 IEA
    S-methyl-5-thioadenosine phosphorylase activity GO:0017061 IBA
    phosphorylase activity GO:0004645 IEA
    transferase activity, transferring pentosyl groups GO:0016763 IEA
    transferase activity GO:0016740 IEA
    transferase activity, transferring glycosyl groups GO:0016757 IEA
Biological Process
    nucleoside metabolic process GO:0009116 IEA
    purine ribonucleoside salvage GO:0006166 IEA
    methylation GO:0032259 IMP
    purine-containing compound salvage GO:0043101 IBA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Mtap in exosomes
1
Experiment ID 26
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|GAPDH|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
 Protein-protein interactions for Mtap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mtap is involved
PathwayEvidenceSource
Methionine salvage pathway IEA Reactome





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