Gene description for Anxa3
Gene name annexin A3
Gene symbol Anxa3
Other names/aliases Anx3
Species Mus musculus
 Database cross references - Anxa3
ExoCarta ExoCarta_11745
Entrez Gene 11745
UniProt O35639  
 Anxa3 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Mov neuroglial cells 15210972    
 Gene ontology annotations for Anxa3
Molecular Function
    calcium ion binding GO:0005509 IEA
    calcium-dependent protein binding GO:0048306 ISO
    calcium-dependent phospholipid binding GO:0005544 ISO
    phospholipase inhibitor activity GO:0004859 IEA
    phospholipase A2 inhibitor activity GO:0019834 ISO
Biological Process
    positive regulation of angiogenesis GO:0045766 ISO
    defense response to bacterium GO:0042742 ISO
    negative regulation of catalytic activity GO:0043086 ISO
    positive regulation of DNA metabolic process GO:0051054 ISO
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    phagocytosis GO:0006909 ISO
    positive regulation of endothelial cell migration GO:0010595 ISO
    neutrophil degranulation GO:0043312 ISO
Subcellular Localization
    specific granule GO:0042581 ISO
    phagocytic vesicle membrane GO:0030670 ISO
    axon GO:0030424 ISO
    plasma membrane GO:0005886 ISO
    neuronal cell body GO:0043025 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    dendrite GO:0030425 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Anxa3 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 39
ISEV standards
IEM
EV Biophysical techniques
TSG101|HSC70
EV Cytosolic markers
FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Anxa3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Anxa3 is involved
No pathways found





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