Gene description for Eif2ak2
Gene name	eukaryotic translation initiation factor 2-alpha kinase 2
Gene symbol	Eif2ak2
Other names/aliases	2310047A08Rik 4732414G15Rik AI467567 AI747578 Pkr Prkr Tik
Species	Mus musculus
Database cross references - Eif2ak2
ExoCarta	ExoCarta_19106
Vesiclepedia	VP_19106
Entrez Gene	19106
UniProt	Q03963
Eif2ak2 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Eif2ak2

Molecular Function     double-stranded RNA binding GO:0003725 IDA     double-stranded RNA binding GO:0003725 ISO     protein kinase activity GO:0004672 IDA     protein kinase activity GO:0004672 IMP     protein kinase activity GO:0004672 ISO     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IBA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 ISO     ribosomal protein S6 kinase activity GO:0004711 IEA     non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     kinase activity GO:0016301 ISO     histone H3S10 kinase activity GO:0035175 IEA     histone H3Y41 kinase activity GO:0035401 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2AXY142 kinase activity GO:0140801 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     positive regulation of cytokine production GO:0001819 IMP     chromatin remodeling GO:0006338 IEA     translation GO:0006412 IDA     regulation of translational initiation GO:0006446 IBA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 ISO     response to virus GO:0009615 ISO     response to virus GO:0009615 ISS     response to toxic substance GO:0009636 ISO     negative regulation of translation GO:0017148 IBA     negative regulation of translation GO:0017148 ISO     negative regulation of translation GO:0017148 ISS     endoplasmic reticulum unfolded protein response GO:0030968 IDA     response to lipopolysaccharide GO:0032496 ISO     positive regulation of chemokine production GO:0032722 IMP     positive regulation of stress-activated MAPK cascade GO:0032874 IMP     response to vitamin E GO:0033197 ISO     negative regulation of osteoblast proliferation GO:0033689 ISO     negative regulation of osteoblast proliferation GO:0033689 ISS     cellular response to amino acid starvation GO:0034198 IEA     cellular response to amino acid starvation GO:0034198 ISO     response to interferon-alpha GO:0035455 ISO     response to interferon-alpha GO:0035455 ISS     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of apoptotic process GO:0043066 IGI     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of MAPK cascade GO:0043410 ISS     negative regulation of viral genome replication GO:0045071 IMP     negative regulation of viral genome replication GO:0045071 ISO     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     antiviral innate immune response GO:0140374 IEA     antiviral innate immune response GO:0140374 ISO     regulation of NLRP3 inflammasome complex assembly GO:1900225 IMP     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 IMP     regulation of hematopoietic progenitor cell differentiation GO:1901532 IMP     regulation of hematopoietic stem cell proliferation GO:1902033 IMP     regulation of hematopoietic stem cell differentiation GO:1902036 IMP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     perinuclear region of cytoplasm GO:0048471 ISO     perinuclear region of cytoplasm GO:0048471 ISS