Gene description for Eif2ak2
Gene name eukaryotic translation initiation factor 2-alpha kinase 2
Gene symbol Eif2ak2
Other names/aliases 2310047A08Rik
Species Mus musculus
 Database cross references - Eif2ak2
ExoCarta ExoCarta_19106
Entrez Gene 19106
UniProt Q03963  
 Eif2ak2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Eif2ak2
Molecular Function
    double-stranded RNA binding GO:0003725 ISO
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 IEA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    poly(A) RNA binding GO:0044822 ISO
    protein tyrosine kinase activity GO:0004713 IEA
    kinase activity GO:0016301 IEA
    transferase activity GO:0016740 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
Biological Process
    response to toxic substance GO:0009636 ISO
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO
    positive regulation of stress-activated MAPK cascade GO:0032874 IMP
    phosphorylation GO:0016310 IEA
    response to interferon-alpha GO:0035455 ISO
    regulation of hematopoietic stem cell differentiation GO:1902036 IMP
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of apoptotic process GO:0043066 IGI
    defense response to virus GO:0051607 IEA
    negative regulation of viral genome replication GO:0045071 ISO
    regulation of hematopoietic stem cell proliferation GO:1902033 IMP
    transcription, DNA-templated GO:0006351 IEA
    immune system process GO:0002376 IEA
    regulation of NLRP3 inflammasome complex assembly GO:1900225 IMP
    response to virus GO:0009615 ISO
    innate immune response GO:0045087 IEA
    positive regulation of chemokine production GO:0032722 IMP
    positive regulation of cytokine production GO:0001819 IMP
    response to vitamin E GO:0033197 ISO
    activation of MAPKK activity GO:0000186 ISO
    positive regulation of NIK/NF-kappaB signaling GO:1901224 IMP
    translation GO:0006412 IDA
    regulation of hematopoietic progenitor cell differentiation GO:1901532 IMP
    protein phosphorylation GO:0006468 ISO
    response to lipopolysaccharide GO:0032496 ISO
    endoplasmic reticulum unfolded protein response GO:0030968 IDA
    negative regulation of osteoblast proliferation GO:0033689 ISO
    negative regulation of translation GO:0017148 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    protein autophosphorylation GO:0046777 ISO
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Eif2ak2 in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Eif2ak2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Eif2ak2 is involved
No pathways found

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