Gene description for Adar
Gene name adenosine deaminase, RNA-specific
Gene symbol Adar
Other names/aliases AV242451
Adar1
Adar1p110
Adar1p150
mZaADAR
Species Mus musculus
 Database cross references - Adar
ExoCarta ExoCarta_56417
Entrez Gene 56417
UniProt Q99MU3  
 Adar identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Adar
Molecular Function
    left-handed Z-DNA binding GO:0003692 TAS
    double-stranded RNA adenosine deaminase activity GO:0003726 ISO
    adenosine deaminase activity GO:0004000 IEA
    hydrolase activity GO:0016787 IEA
    poly(A) RNA binding GO:0044822 ISO
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 IEA
    double-stranded RNA binding GO:0003725 ISO
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
Biological Process
    production of miRNAs involved in gene silencing by miRNA GO:0035196 IMP
    osteoblast differentiation GO:0001649 IMP
    base conversion or substitution editing GO:0016553 ISO
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of RNA interference GO:1900369 IMP
    hematopoietic stem cell homeostasis GO:0061484 IMP
    positive regulation of viral genome replication GO:0045070 ISO
    innate immune response GO:0045087 IEA
    response to virus GO:0009615 ISO
    protein import into nucleus GO:0006606 ISO
    in utero embryonic development GO:0001701 IMP
    negative regulation of viral genome replication GO:0045071 IMP
    erythrocyte differentiation GO:0030218 IMP
    mRNA processing GO:0006397 IEA
    immune system process GO:0002376 IEA
    response to interferon-alpha GO:0035455 ISO
    gene silencing by RNA GO:0031047 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IMP
    defense response to virus GO:0051607 IMP
    protein export from nucleus GO:0006611 ISO
    negative regulation of apoptotic process GO:0043066 IMP
    adenosine to inosine editing GO:0006382 ISO
    somatic diversification of immune receptors via somatic mutation GO:0002566 IDA
    definitive hemopoiesis GO:0060216 IMP
    negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 ISO
    RNA processing GO:0006396 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of type I interferon-mediated signaling pathway GO:0060339 IMP
    miRNA loading onto RISC involved in gene silencing by miRNA GO:0035280 ISO
    pre-miRNA processing GO:0031054 ISO
Subcellular Localization
    supraspliceosomal complex GO:0044530 ISO
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Adar in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Adar
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adar is involved
PathwayEvidenceSource
C6 deamination of adenosine IEA Reactome
Formation of editosomes by ADAR proteins IEA Reactome





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