Gene description for LRRC8C
Gene name leucine rich repeat containing 8 family, member C
Gene symbol LRRC8C
Other names/aliases AD158
FAD158
Species Homo sapiens
 Database cross references - LRRC8C
ExoCarta ExoCarta_84230
Entrez Gene 84230
HGNC 25075
MIM 612889
UniProt Q8TDW0  
 LRRC8C identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for LRRC8C
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    ion transport GO:0006811 IEA
    fat cell differentiation GO:0045444 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LRRC8C in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LRRC8C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LRRC8C is involved
No pathways found





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