Gene description for KLB
Gene name klotho beta
Gene symbol KLB
Other names/aliases BKL
Species Homo sapiens
 Database cross references - KLB
ExoCarta ExoCarta_152831
Entrez Gene 152831
HGNC 15527
MIM 611135
UniProt Q86Z14  
 KLB identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for KLB
Molecular Function
    fibroblast growth factor binding GO:0017134 IPI
    fibroblast growth factor receptor binding GO:0005104 IPI
    protein binding GO:0005515 IPI
    hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 IEA
Biological Process
    innate immune response GO:0045087 TAS
    carbohydrate metabolic process GO:0005975 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    insulin receptor signaling pathway GO:0008286 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    intracellular GO:0005622 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified KLB in exosomes
Experiment ID 226
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for KLB
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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