Gene description for KLB
Gene name klotho beta
Gene symbol KLB
Other names/aliases BKL
Species Homo sapiens
 Database cross references - KLB
ExoCarta ExoCarta_152831
Vesiclepedia VP_152831
Entrez Gene 152831
HGNC 15527
MIM 611135
UniProt Q86Z14  
 KLB identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for KLB
Molecular Function
    hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 IEA
    fibroblast growth factor receptor binding GO:0005104 IPI
    protein binding GO:0005515 IPI
    fibroblast growth factor binding GO:0017134 IPI
Biological Process
    carbohydrate metabolic process GO:0005975 IEA
    positive regulation of cell population proliferation GO:0008284 IEA
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified KLB in exosomes
1
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for KLB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGFR1 2260
Affinity Capture-Western Homo sapiens
2 KIF20A 10112
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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