Gene description for LAT2
Gene name linker for activation of T cells family, member 2
Gene symbol LAT2
Other names/aliases HSPC046
LAB
NTAL
WBSCR15
WBSCR5
WSCR5
Species Homo sapiens
 Database cross references - LAT2
ExoCarta ExoCarta_7462
Entrez Gene 7462
HGNC 12749
MIM 605719
UniProt Q9GZY6  
 LAT2 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for LAT2
Molecular Function
    SH2 domain binding GO:0042169 IPI
    protein binding GO:0005515 IPI
Biological Process
    innate immune response GO:0045087 TAS
    mast cell degranulation GO:0043303 IEA
    B cell receptor signaling pathway GO:0050853 IDA
    calcium-mediated signaling GO:0019722 IGI
    intracellular signal transduction GO:0035556 IGI
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    B cell activation GO:0042113 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    mast cell granule GO:0042629 IEA
    extracellular exosome GO:0070062 IDA
    intracellular GO:0005622 IGI
    membrane raft GO:0045121 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified LAT2 in exosomes
1
Experiment ID 79
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|MHCII
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for LAT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLCG2 5336
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 PLCG1 5335
Affinity Capture-Western Homo sapiens
3 BLNK  
Affinity Capture-MS Homo sapiens
4 GRB2 2885
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which LAT2 is involved
PathwayEvidenceSource
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome





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