Gene description for TMEM38A
Gene name transmembrane protein 38A
Gene symbol TMEM38A
Other names/aliases TRIC-A
TRICA
Species Homo sapiens
 Database cross references - TMEM38A
ExoCarta ExoCarta_79041
Vesiclepedia VP_79041
Entrez Gene 79041
HGNC 28462
MIM 611235
UniProt Q9H6F2  
 TMEM38A identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TMEM38A
Molecular Function
    potassium channel activity GO:0005267 ISS
    potassium channel activity GO:0005267 TAS
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    endoplasmic reticulum organization GO:0007029 IEA
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 IEA
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 IEA
    regulation of release of sequestered calcium ion into cytosol GO:0051279 ISS
    cellular response to caffeine GO:0071313 IEA
    potassium ion transmembrane transport GO:0071805 IEA
Subcellular Localization
    nuclear membrane GO:0031965 ISS
    nuclear membrane GO:0031965 NAS
    sarcoplasmic reticulum membrane GO:0033017 ISS
    sarcoplasmic reticulum membrane GO:0033017 NAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TMEM38A in sEVs
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TMEM38A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OXLD1  
Affinity Capture-MS Homo sapiens
2 HSD3B2 3284
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PCP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 DOK2 9046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ARRB2 409
Affinity Capture-MS Homo sapiens
6 NCEH1 57552
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LZTFL1 54585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM38A is involved
No pathways found





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