Gene description for Scai
Gene name suppressor of cancer cell invasion
Gene symbol Scai
Other names/aliases 9330112M16
A930041I02Rik
AI662729
Species Mus musculus
 Database cross references - Scai
ExoCarta ExoCarta_320271
Entrez Gene 320271
UniProt Q8C8N2  
 Scai identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Scai
Molecular Function
    transcription corepressor activity GO:0003714 ISO
    protein binding GO:0005515 IPI
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of cell migration GO:0030336 ISO
    negative regulation of signal transduction GO:0009968 IEA
    negative regulation of nucleic acid-templated transcription GO:1903507 ISO
    negative regulation of Rho protein signal transduction GO:0035024 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    nuclear membrane GO:0031965 ISO
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Scai in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Scai
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Scai is involved
PathwayEvidenceSource
RHO GTPases Activate Formins IEA Reactome





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