Gene description for SLC22A12
Gene name solute carrier family 22 (organic anion/urate transporter), member 12
Gene symbol SLC22A12
Other names/aliases OAT4L
RST
URAT1
Species Homo sapiens
 Database cross references - SLC22A12
ExoCarta ExoCarta_116085
Entrez Gene 116085
HGNC 17989
MIM 607096
UniProt Q96S37  
 SLC22A12 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A12
Molecular Function
    PDZ domain binding GO:0030165 IPI
    urate transmembrane transporter activity GO:0015143 IDA
Biological Process
    urate metabolic process GO:0046415 IMP
    organic acid transmembrane transport GO:1903825 IEA
    urate transport GO:0015747 IDA
    response to drug GO:0042493 IDA
    cellular homeostasis GO:0019725 NAS
    transmembrane transport GO:0055085 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 IDA
    brush border membrane GO:0031526 NAS
    integral component of membrane GO:0016021 IDA
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified SLC22A12 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDZK1 5174
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SLC22A12 is involved
PathwayEvidenceSource
Organic anion transport TAS Reactome





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