Gene description for SLC22A5
Gene name solute carrier family 22 (organic cation/carnitine transporter), member 5
Gene symbol SLC22A5
Other names/aliases CDSP
OCTN2
Species Homo sapiens
 Database cross references - SLC22A5
ExoCarta ExoCarta_6584
Vesiclepedia VP_6584
Entrez Gene 6584
HGNC 10969
MIM 603377
UniProt O76082  
 SLC22A5 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A5
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    amino-acid betaine transmembrane transporter activity GO:0015199 IDA
    carnitine transmembrane transporter activity GO:0015226 EXP
    carnitine transmembrane transporter activity GO:0015226 IDA
    carnitine transmembrane transporter activity GO:0015226 IMP
    carnitine transmembrane transporter activity GO:0015226 TAS
    symporter activity GO:0015293 IEA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IBA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IMP
    PDZ domain binding GO:0030165 IPI
    xenobiotic transmembrane transporter activity GO:0042910 IC
    (R)-carnitine transmembrane transporter activity GO:1901235 IDA
    (R)-carnitine transmembrane transporter activity GO:1901235 IDA
    (R)-carnitine transmembrane transporter activity GO:1901235 IMP
    (R)-carnitine transmembrane transporter activity GO:1901235 ISS
Biological Process
    sodium ion transport GO:0006814 IEA
    response to symbiotic bacterium GO:0009609 IMP
    quaternary ammonium group transport GO:0015697 IBA
    quaternary ammonium group transport GO:0015697 IDA
    quaternary ammonium group transport GO:0015697 IMP
    carnitine transport GO:0015879 IDA
    carnitine transport GO:0015879 IMP
    response to type II interferon GO:0034341 IDA
    response to tumor necrosis factor GO:0034612 IDA
    positive regulation of intestinal epithelial structure maintenance GO:0060731 IMP
    sodium-dependent organic cation transport GO:0070715 IDA
    transport across blood-brain barrier GO:0150104 ISS
    transport across blood-brain barrier GO:0150104 NAS
    (R)-carnitine transport GO:1900749 IDA
    (R)-carnitine transport GO:1900749 IDA
    (R)-carnitine transmembrane transport GO:1902270 IDA
    (R)-carnitine transmembrane transport GO:1902270 IMP
    (R)-carnitine transmembrane transport GO:1902270 ISS
    carnitine transmembrane transport GO:1902603 TAS
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IC
Subcellular Localization
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    basal plasma membrane GO:0009925 IDA
    apical plasma membrane GO:0016324 IDA
    brush border membrane GO:0031526 IDA
    brush border membrane GO:0031526 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLC22A5 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT27 342574
Two-hybrid Homo sapiens
2 KLRC4  
Affinity Capture-MS Homo sapiens
3 NOTCH2NL 388677
Two-hybrid Homo sapiens
4 LAMP1 3916
Proximity Label-MS Homo sapiens
5 KRAS 3845
Proximity Label-MS Homo sapiens
6 KRT34  
Two-hybrid Homo sapiens
7 YIPF3 25844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ARF6 382
Proximity Label-MS Homo sapiens
9 PDZK1 5174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SLC22A4 6583
Affinity Capture-MS Homo sapiens
11 MTUS2 23281
Two-hybrid Homo sapiens
12 CLGN 1047
Affinity Capture-MS Homo sapiens
13 CXCR4 7852
Affinity Capture-MS Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 HMGCS1 3157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SH3RF1  
Two-hybrid Homo sapiens
17 KRTAP6-3  
Two-hybrid Homo sapiens
18 LAMP3  
Proximity Label-MS Homo sapiens
19 NBPF19  
Two-hybrid Homo sapiens
20 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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