Gene description for SLC22A5
Gene name solute carrier family 22 (organic cation/carnitine transporter), member 5
Gene symbol SLC22A5
Other names/aliases CDSP
OCTN2
Species Homo sapiens
 Database cross references - SLC22A5
ExoCarta ExoCarta_6584
Entrez Gene 6584
HGNC 10969
MIM 603377
UniProt O76082  
 SLC22A5 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLC22A5
Molecular Function
    PDZ domain binding GO:0030165 IPI
    antibiotic transporter activity GO:0042895 IEA
    ATP binding GO:0005524 IEA
    quaternary ammonium group transmembrane transporter activity GO:0015651 IDA
    carnitine transmembrane transporter activity GO:0015226 IMP
    symporter activity GO:0015293 IEA
    drug transmembrane transporter activity GO:0015238 IC
    protein binding GO:0005515 IPI
Biological Process
    drug transmembrane transport GO:0006855 IC
    antibiotic transport GO:0042891 IEA
    transmembrane transport GO:0055085 TAS
    sodium-dependent organic cation transport GO:0070715 IDA
    drug transport GO:0015893 IC
    carnitine transport GO:0015879 IMP
    quorum sensing involved in interaction with host GO:0052106 IMP
    quaternary ammonium group transport GO:0015697 IDA
    sodium ion transport GO:0006814 IEA
    positive regulation of intestinal epithelial structure maintenance GO:0060731 IMP
    carnitine transmembrane transport GO:1902603 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 TAS
    brush border membrane GO:0031526 ISS
    apical plasma membrane GO:0016324 IDA
    integral component of membrane GO:0016021 IEA
    basolateral plasma membrane GO:0016323 IEA
 Experiment description of studies that identified SLC22A5 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLC22A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC22A5 is involved
PathwayEvidenceSource
Organic cation transport TAS Reactome





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