Gene description for CRTC2
Gene name CREB regulated transcription coactivator 2
Gene symbol CRTC2
Other names/aliases TORC-2
TORC2
Species Homo sapiens
 Database cross references - CRTC2
ExoCarta ExoCarta_200186
Vesiclepedia VP_200186
Entrez Gene 200186
HGNC 27301
MIM 608972
UniProt Q53ET0  
 CRTC2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CRTC2
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    protein binding GO:0005515 IPI
    cAMP response element binding protein binding GO:0008140 IBA
Biological Process
    gluconeogenesis GO:0006094 ISS
    positive regulation of CREB transcription factor activity GO:0032793 ISS
    glucose homeostasis GO:0042593 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    protein homotetramerization GO:0051289 IEA
    cellular response to cAMP GO:0071320 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CRTC2 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CRTC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 LRFN1  
Affinity Capture-MS Homo sapiens
4 ACTR2 10097
Affinity Capture-MS Homo sapiens
5 GTSE1 51512
Affinity Capture-MS Homo sapiens
6 PRKAA1 5562
Biochemical Activity Homo sapiens
7 PPP3CA 5530
Affinity Capture-Western Homo sapiens
8 PPP3R1 5534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 Stat3 20848
Affinity Capture-Western Mus musculus
10 KSR1  
Affinity Capture-MS Homo sapiens
11 TP53 7157
Affinity Capture-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 PIP 5304
Affinity Capture-MS Homo sapiens
14 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RFWD2  
Affinity Capture-Western Homo sapiens
16 CCDC57 284001
Two-hybrid Homo sapiens
17 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SUFU 51684
Two-hybrid Homo sapiens
19 TRAF6 7189
Affinity Capture-Western Homo sapiens
20 RC3H2  
Affinity Capture-MS Homo sapiens
21 KIF13B 23303
Affinity Capture-MS Homo sapiens
22 CDKN1A  
Affinity Capture-MS Homo sapiens
23 CBY1  
Affinity Capture-MS Homo sapiens
24 NUP35 129401
Proximity Label-MS Homo sapiens
25 CREB1  
Two-hybrid Homo sapiens
26 ARL6IP6  
Affinity Capture-MS Homo sapiens
27 Sec24c  
Affinity Capture-MS Mus musculus
28 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
29 HIST1H3B 8358
Affinity Capture-Western Homo sapiens
30 CEP250 11190
Affinity Capture-MS Homo sapiens
31 CGN  
Affinity Capture-MS Homo sapiens
32 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HECW2  
Affinity Capture-MS Homo sapiens
34 WDYHV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 NEDD1 121441
Affinity Capture-MS Homo sapiens
36 ZBTB21  
Affinity Capture-MS Homo sapiens
37 GIGYF1  
Affinity Capture-MS Homo sapiens
38 DTX2 113878
Proximity Label-MS Homo sapiens
39 PPP3CB  
Affinity Capture-MS Homo sapiens
40 ATPAF2 91647
Two-hybrid Homo sapiens
41 PPP3CC 5533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 YWHAQ 10971
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CLTC 1213
Affinity Capture-MS Homo sapiens
44 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SIK2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
46 KCTD3  
Affinity Capture-MS Homo sapiens
47 MDM2  
Affinity Capture-Western Homo sapiens
48 EP300 2033
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here