Gene description for CRTC2
Gene name CREB regulated transcription coactivator 2
Gene symbol CRTC2
Other names/aliases TORC-2
TORC2
Species Homo sapiens
 Database cross references - CRTC2
ExoCarta ExoCarta_200186
Entrez Gene 200186
HGNC 27301
MIM 608972
UniProt Q53ET0  
 CRTC2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CRTC2
Molecular Function
    protein binding GO:0005515 IPI
    cAMP response element binding protein binding GO:0008140 IBA
Biological Process
    gluconeogenesis GO:0006094 ISS
    viral process GO:0016032 IEA
    toxin transport GO:1901998 IEA
    positive regulation of CREB transcription factor activity GO:0032793 ISS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA
    histone H3-K9 acetylation GO:0043970 IEA
    protein homotetramerization GO:0051289 IEA
    glucose homeostasis GO:0042593 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 ISS
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified CRTC2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CRTC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAG 7532
Affinity Capture-MS Homo sapiens
2 YWHAQ 10971
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 SNF1LK2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CRTC2 is involved
No pathways found





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