Gene description for ZFP36L2
Gene name ZFP36 ring finger protein-like 2
Gene symbol ZFP36L2
Other names/aliases BRF2
ERF-2
ERF2
RNF162C
TIS11D
Species Homo sapiens
 Database cross references - ZFP36L2
ExoCarta ExoCarta_678
Vesiclepedia VP_678
Entrez Gene 678
HGNC 1108
MIM 612053
UniProt P47974  
 ZFP36L2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ZFP36L2
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    mRNA 3'-UTR AU-rich region binding GO:0035925 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 IEA
    mRNA catabolic process GO:0006402 IMP
    mRNA catabolic process GO:0006402 ISS
    response to wounding GO:0009611 IDA
    hemopoiesis GO:0030097 ISS
    T cell differentiation in thymus GO:0033077 ISS
    somatic stem cell population maintenance GO:0035019 ISS
    regulation of mRNA stability GO:0043488 IMP
    regulation of mRNA stability GO:0043488 ISS
    cellular response to fibroblast growth factor stimulus GO:0044344 IDA
    regulation of B cell differentiation GO:0045577 ISS
    negative regulation of fat cell differentiation GO:0045599 ISS
    somatic stem cell division GO:0048103 ISS
    definitive hemopoiesis GO:0060216 ISS
    3'-UTR-mediated mRNA destabilization GO:0061158 IMP
    3'-UTR-mediated mRNA destabilization GO:0061158 ISS
    ERK1 and ERK2 cascade GO:0070371 IDA
    cellular response to tumor necrosis factor GO:0071356 IDA
    cellular response to epidermal growth factor stimulus GO:0071364 IDA
    cellular response to glucocorticoid stimulus GO:0071385 IDA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IDA
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 ISS
    negative regulation of mitotic cell cycle phase transition GO:1901991 ISS
    negative regulation of stem cell differentiation GO:2000737 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified ZFP36L2 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ZFP36L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 C12orf49  
Negative Genetic Homo sapiens
5 GEMIN5 25929
Affinity Capture-MS Homo sapiens
6 MEN1 4221
Affinity Capture-MS Homo sapiens
7 HIF1AN 55662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 Akt2  
Affinity Capture-MS Mus musculus
9 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SMC6  
Affinity Capture-MS Homo sapiens
11 SQSTM1 8878
Proximity Label-MS Homo sapiens
12 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 LAD1 3898
Affinity Capture-MS Homo sapiens
14 FAM120A 23196
Affinity Capture-MS Homo sapiens
15 NUP43 348995
Proximity Label-MS Homo sapiens
16 CBY1  
Affinity Capture-MS Homo sapiens
17 FASN 2194
Negative Genetic Homo sapiens
18 XPO1 7514
Affinity Capture-MS Homo sapiens
19 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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